{"id":54201,"date":"2022-02-14T15:29:45","date_gmt":"2022-02-14T14:29:45","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=54201"},"modified":"2025-09-11T16:47:59","modified_gmt":"2025-09-11T14:47:59","slug":"similar-gut-hormone-secretions-two-years-after-one-anastomosis-gastric-bypass-and-roux-en-y-gastric-bypass-a-pilot-study","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/similar-gut-hormone-secretions-two-years-after-one-anastomosis-gastric-bypass-and-roux-en-y-gastric-bypass-a-pilot-study\/","title":{"rendered":"Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-54201","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Obes Surg.","date_de_publication":"20220107","numero_doi":"","equipe":[131],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]David De Bandt[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Claire Rives-Lange[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Yvann Frigout[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Damien Bergerot[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Anne Blanchard[:]"},{"texte_libre":false,"auteur-lien":13105,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Jean-Marc Lacorte[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Jean-Marc Chevallier[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]S\u00e9bastien Czernichow[:]"},{"texte_libre":false,"auteur-lien":17376,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Claire Carette[:]"},{"texte_libre":false,"auteur-lien":13100,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/34993850\/"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objectives:\u00a0<\/strong>One-anastomosis gastric bypass (OAGB) is as effective as Roux-en-Y gastric bypass (RYGB) regarding weight loss and diabetes remission. However, there are no data on gut hormone secretions after OAGB. The aim of this study was to compare fasting and postprandial secretions of gut and pancreatic hormones in OAGB versus RYGB patients.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Design and methods:\u00a0<\/strong>Twenty-nine patients, 16 OAGB- and 13 RYGB-operated, underwent a liquid mixed-meal tolerance test at 2 years' post-surgery. Blood was sampled before and 15, 30, 60, 90, and 120 min after meal for plasma measurement of glucose, C-peptide, insulin, glucagon, GLP-1, GIP, GLP-2, PYY, and ghrelin.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Percentage of total weight loss 2 years post-surgery were -33.9 \u00b1 1.8% for OAGB and -31.2 \u00b1 1.6% for RYGB (p = 0.6). Four patients with persistent diabetes were excluded for further analysis. Fasting and postprandial glucose levels (peaks and area under curve values) were similar between groups. HOMA index was lower in the OAGB group (0.8 \u00b1 0.1 vs 1.3 \u00b1 0.2 in RYGB, p &lt; 0.05). Levels of C-peptide (or insulin) measured at 30 min were significantly lower in OAGB vs RYGB patients (6.9 \u00b1 0.5 vs 9.7 \u00b1 1.1 \u00b5g\/l, p &lt; 0.05). No difference was observed between OAGB and RYGB groups for GLP-1, GLP-2, PYY, or ghrelin postprandial secretions, but GIP tended to be lower in OAGB vs RYGB patients (756 \u00b1 155 vs 1100 \u00b1 188 pg\/ml for postprandial peak concentrations, p = 0.06).<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This is the first clinical study showing that OAGB procedure, like RYGB, results in high postprandial secretions of gut hormones, in particular GLP-1.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objectives:\u00a0<\/strong>One-anastomosis gastric bypass (OAGB) is as effective as Roux-en-Y gastric bypass (RYGB) regarding weight loss and diabetes remission. However, there are no data on gut hormone secretions after OAGB. The aim of this study was to compare fasting and postprandial secretions of gut and pancreatic hormones in OAGB versus RYGB patients.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Design and methods:\u00a0<\/strong>Twenty-nine patients, 16 OAGB- and 13 RYGB-operated, underwent a liquid mixed-meal tolerance test at 2 years' post-surgery. Blood was sampled before and 15, 30, 60, 90, and 120 min after meal for plasma measurement of glucose, C-peptide, insulin, glucagon, GLP-1, GIP, GLP-2, PYY, and ghrelin.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Percentage of total weight loss 2 years post-surgery were -33.9 \u00b1 1.8% for OAGB and -31.2 \u00b1 1.6% for RYGB (p = 0.6). Four patients with persistent diabetes were excluded for further analysis. Fasting and postprandial glucose levels (peaks and area under curve values) were similar between groups. HOMA index was lower in the OAGB group (0.8 \u00b1 0.1 vs 1.3 \u00b1 0.2 in RYGB, p &lt; 0.05). Levels of C-peptide (or insulin) measured at 30 min were significantly lower in OAGB vs RYGB patients (6.9 \u00b1 0.5 vs 9.7 \u00b1 1.1 \u00b5g\/l, p &lt; 0.05). No difference was observed between OAGB and RYGB groups for GLP-1, GLP-2, PYY, or ghrelin postprandial secretions, but GIP tended to be lower in OAGB vs RYGB patients (756 \u00b1 155 vs 1100 \u00b1 188 pg\/ml for postprandial peak concentrations, p = 0.06).<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>This is the first clinical study showing that OAGB procedure, like RYGB, results in high postprandial secretions of gut hormones, in particular GLP-1.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/similar-gut-hormone-secretions-two-years-after-one-anastomosis-gastric-bypass-and-roux-en-y-gastric-bypass-a-pilot-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study. - 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