{"id":17380,"date":"2021-02-15T17:18:15","date_gmt":"2021-02-15T16:18:15","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=17380"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"bariatric-surgery-induces-a-new-gastric-mucosa-phenotype-with-increased-functional-glucagon-like-peptide-1-expressing-cells","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/bariatric-surgery-induces-a-new-gastric-mucosa-phenotype-with-increased-functional-glucagon-like-peptide-1-expressing-cells\/","title":{"rendered":"Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-17380","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Nature Communications","date_de_publication":"20210104","numero_doi":"","equipe":[131],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13175,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Anne-Charlotte Jarry[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Jean-Baptiste Cavin[:]"},{"texte_libre":false,"auteur-lien":13199,"auteur-text":""},{"texte_libre":false,"auteur-lien":13100,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Aur\u00e9lie Sannier[:]"},{"texte_libre":false,"auteur-lien":13032,"auteur-text":""},{"texte_libre":false,"auteur-lien":13138,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Muriel Hourseau[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Thibaut L\u00e9ger[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Bastien Morlet[:]"},{"texte_libre":false,"auteur-lien":13054,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:en]Younes Anini[:]"},{"texte_libre":false,"auteur-lien":13126,"auteur-text":""},{"texte_libre":false,"auteur-lien":13116,"auteur-text":""},{"texte_libre":false,"auteur-lien":13241,"auteur-text":""},{"texte_libre":false,"auteur-lien":13105,"auteur-text":""},{"texte_libre":false,"auteur-lien":13025,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/s41467-020-20301-1?utm_source=other&utm_medium=other&utm_content=null&utm_campaign=JRCN_1_LW01_CN_natureOA_article_paid_XMOL"}],"paragraphe":"[:en]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical\u00a0sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:en]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical\u00a0sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/bariatric-surgery-induces-a-new-gastric-mucosa-phenotype-with-increased-functional-glucagon-like-peptide-1-expressing-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells - 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