{"id":16224,"date":"2020-12-07T17:48:49","date_gmt":"2020-12-07T16:48:49","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=16224"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"endocannabinoid-receptor-1-and-sympathetic-nervous-system-mediate-the-beneficial-metabolic-effects-of-gastric-bypass","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/endocannabinoid-receptor-1-and-sympathetic-nervous-system-mediate-the-beneficial-metabolic-effects-of-gastric-bypass\/","title":{"rendered":"Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-16224","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Cell Rep","date_de_publication":"20201027","numero_doi":"","equipe":[131],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Yuanchao Ye[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Marwa Abu El Haija[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Donald A Morgan[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Deng Guo[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Yang Song[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Aaron Frank[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Liping Tian[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Ruth A Riedl[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Colin M L Burnett[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Zhan Gao[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Zhiyong Zhu[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Shailesh K Shahi[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Kasra Zarei[:]"},{"texte_libre":false,"auteur-lien":13054,"auteur-text":""},{"texte_libre":false,"auteur-lien":13204,"auteur-text":""},{"texte_libre":false,"auteur-lien":13175,"auteur-text":""},{"texte_libre":false,"auteur-lien":13025,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Lama Noureddine[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Andrew Bellizzi[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Paul Kievit[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Ashutosh K Mangalam[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Leonid V Zingman[:]"},{"texte_libre":false,"auteur-lien":13105,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Justin L Grobe[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Lee M Kaplan[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Deborah Clegg[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Kamal Rahmouni[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Mohamad Mokadem[:]"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/33113371\/"}],"paragraphe":"[:fr]<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>Chirurgie bariatrique et diff\u00e9rences dans la r\u00e9gulation du m\u00e9tabolisme\u00a0de base<\/strong><\/span><\/p>\r\n<p style=\"text-align: justify;\">Dans un article publi\u00e9 dans la revue <em>Cell Reports <\/em>(octobre 2020), l\u2019\u00e9quipe de recherche PIMS, dirig\u00e9e par Maude Le Gall et Andr\u00e9 Bado, d\u00e9montre que la r\u00e9gulation du m\u00e9tabolisme de base du patient ob\u00e8se op\u00e9r\u00e9 diff\u00e8re selon la chirurgie bariatrique utilis\u00e9e\u00a0: le bypass gastrique dit \u00ab\u00a0de type Roux-en-Y\u00a0\u00bb (RYGB) ou la sleeve gastrectomie (SG). Ces travaux ont \u00e9t\u00e9 men\u00e9s en collaboration avec des chercheurs de l\u2019Universit\u00e9 de l\u2019Iowa (Etats-Unis).<\/p>\r\n<p style=\"text-align: justify;\">\u00c0 l\u2019heure actuelle, il existe peu ou pas de th\u00e9rapies pharmacologiques et comportementales efficaces pour la prise en charge de l\u2019ob\u00e9sit\u00e9 s\u00e9v\u00e8re. La chirurgie bariatrique reste le traitement le plus efficace, le RYGB (proc\u00e9dure de r\u00e9f\u00e9rence) et la SG \u00e9tant les techniques les plus utilis\u00e9es. En plus de la perte de poids et de son maintien \u00e0 long terme, le RYGB et la SG am\u00e9liorent la dyslipid\u00e9mie, la st\u00e9atose h\u00e9patique non alcoolique et le diab\u00e8te de type 2 chez les patients op\u00e9r\u00e9s, parfois avant m\u00eame la perte de poids. Cependant, les m\u00e9canismes sous-jacents de ces effets b\u00e9n\u00e9fiques sont complexes et restent discut\u00e9s.<\/p>\r\n<p style=\"text-align: justify;\">Dans cette \u00e9tude, les chercheurs ont d\u00e9montr\u00e9, en utilisant une combinaison de calorim\u00e9trie directe et indirecte, une augmentation du m\u00e9tabolisme de base, en particulier sa composante ana\u00e9robie apr\u00e8s RYGB, mais pas apr\u00e8s SG. Cette augmentation \u00e9tait associ\u00e9e \u00e0 une augmentation sp\u00e9cifique de l\u2019activit\u00e9 nerveuse sympathique splanchnique et \u00e0 un \u00ab brunissement \u00bb du tissu adipeux m\u00e9sent\u00e9rique.<\/p>\r\n<p style=\"text-align: justify;\">Parmi leurs principales observations\u00a0:<\/p>\r\n<ul style=\"text-align: justify;\">\r\n\t<li>la d\u00e9nervation splanchnique s\u00e9lective supprime tous les effets b\u00e9n\u00e9fiques du RYGB par des m\u00e9canismes impliquant la signalisation endocannabino\u00efde dans l'intestin gr\u00eale.<\/li>\r\n\t<li>l'administration d\u2019un antagoniste du r\u00e9cepteur endocannabino\u00efde-1 (CB1), \u00e0 des souris ob\u00e8ses mime les effets sp\u00e9cifiques de la chirurgie RYGB sur le m\u00e9tabolisme tandis que celle d\u2019un agoniste CB1, en att\u00e9nue les effets.<\/li>\r\n<\/ul>\r\n<p style=\"text-align: justify;\">Ces r\u00e9sultats identifient le r\u00e9cepteur CB1 comme un acteur important du m\u00e9tabolisme de base apr\u00e8s une chirurgie RYGB par l\u2019interm\u00e9diaire d\u2019une voie impliquant le syst\u00e8me nerveux sympathique. Ce r\u00e9cepteur pourrait ainsi repr\u00e9senter une cible th\u00e9rapeutique d\u2019int\u00e9r\u00eat pour le traitement de l\u2019ob\u00e9sit\u00e9 associ\u00e9e au diab\u00e8te de type 2.<\/p>\r\n<p>&nbsp;<\/p>\r\n<p style=\"text-align: center;\"><em>Cell Rep. 2020 33(4): 108270. doi:10.1016<\/em><\/p>\r\n<p><a href=\"https:\/\/cri1149.fr\/?attachment_id=16225\" rel=\"attachment wp-att-16225\"><img class=\"aligncenter  wp-image-16225\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/12\/cell-report-maude-300x172.png\" alt=\"\" width=\"563\" height=\"323\" \/><\/a><\/p>[:]","paragraphe_en":"[:en]<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"> <strong> Bariatric surgery and differences in the regulation of basal metabolism<\/strong><\/span><\/p>\r\n<p style=\"text-align: justify;\">In an article published in the journal <em> Cell Reports <\/em> (October 2020), the PIMS research team, led by Maude Le Gall and Andr\u00e9 Bado, shows that the regulation of the basic metabolism of the operated obese patient differs according to the bariatric surgery used: the gastric bypass known as \u201cof the Roux-en-Y type\u201d (RYGB) or the sleeve gastrectomy (SG). This work was carried out in collaboration with researchers from the University of Iowa (USA).<\/p>\r\n<p style=\"text-align: justify;\">Currently, there are few or no effective pharmacological and behavioral therapies for the management of severe obesity. Bariatric surgery remains the most effective treatment, with RYGB (standard procedure) and SG being the most used techniques. In addition to weight loss and its long-term maintenance, RYGB and SG improve dyslipidemia, non-alcoholic fatty liver disease, and type 2 diabetes in operated patients, sometimes even before weight loss. However, the mechanisms underlying these beneficial effects are complex and remain debated.<\/p>\r\n<p style=\"text-align: justify;\">In this study, researchers demonstrated, using a combination of direct and indirect calorimetry, an increase in basal metabolism, in particular its anaerobic component after RYGB, but not after SG. This increase was associated with a specific increase in splanchnic sympathetic nerve activity and \"browning\" of the mesenteric adipose tissue.<\/p>\r\n<p style=\"text-align: justify;\">Among their main observations:<\/p>\r\n<ul style=\"text-align: justify;\">\r\n\t<li>Selective splanchnic denervation suppresses all beneficial effects of RYGB by mechanisms involving endocannabinoid signaling in the small intestine.<\/li>\r\n\t<li>Administration of an endocannabinoid-1 (CB1) receptor antagonist to obese mice mimics the specific effects of RYGB surgery on metabolism, while that of a CB1 agonist attenuates its effects.\u00a0<\/li>\r\n<\/ul>\r\n<p style=\"text-align: justify;\">These results identify the CB1 receptor as an important player in basal metabolism after RYGB surgery via a pathway involving the sympathetic nervous system. This receptor could therefore represent a therapeutic target of interest for the treatment of obesity associated with type 2 diabetes.<\/p>\r\n<p>&nbsp;<\/p>\r\n<p style=\"text-align: center;\"><em> Cell Rep. 2020 33 (4): 108270. doi: 10.1016 <\/em><\/p>\r\n<p><a href=\"https:\/\/cri1149.fr\/?attachment_id=16225\" rel=\"attachment wp-att-16225\"><img class=\"aligncenter  wp-image-16225\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/12\/cell-report-maude-300x172.png\" alt=\"\" width=\"616\" height=\"353\" \/><\/a><\/p>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/endocannabinoid-receptor-1-and-sympathetic-nervous-system-mediate-the-beneficial-metabolic-effects-of-gastric-bypass\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass - 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