{"id":16054,"date":"2020-10-22T11:04:33","date_gmt":"2020-10-22T09:04:33","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=16054"},"modified":"2025-09-11T16:48:00","modified_gmt":"2025-09-11T14:48:00","slug":"dietary-emulsifiers-directly-impact-adherentinvasive-e-coli-gene-expression-to-drive-chronic-intestinal-inflammation","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/dietary-emulsifiers-directly-impact-adherentinvasive-e-coli-gene-expression-to-drive-chronic-intestinal-inflammation\/","title":{"rendered":"Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-16054","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Cell Reports","date_de_publication":"20201006","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14593,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Alexis Bretin[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Philip E. Dube[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Alexander C. Maue[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Charle` ne J.G. Dauriat[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Nicolas Barnich[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Andrew T. Gewirtz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Benoit Chassaing[:]"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(20)31218-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124720312183%3Fshowall%3Dtrue"}],"paragraphe":"<p style=\"text-align: justify;\">Dans une \u00e9tude r\u00e9cente, les chercheurs Inserm Benoit Chassaing (Institut Cochin, unit\u00e9 Inserm 1016 \/ CNRS \/ Universit\u00e9 de Paris) et Emilie Viennois (Centre de Recherche sur l\u2019Inflammation, unit\u00e9 Inserm 1149 \/ Universit\u00e9 de Paris) ont \u00e9lucid\u00e9 les m\u00e9canismes par lesquels certains agents \u00e9mulsifiants alimentaires peuvent avoir un impact n\u00e9gatif sur le microbiote intestinal et favorisent l'inflammation intestinale, mettant ainsi en \u00e9vidence des \u00e9volutions possibles dans la prise en charge de l'inflammation intestinale chronique.\u00a0Leurs r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans le journal\u00a0<em>Cell Reports<\/em>.<\/p>\r\n<h3 style=\"text-align: justify;\">Le contexte<\/h3>\r\n<p style=\"text-align: justify;\">Les \u00e9mulsifiants alimentaires sont des compos\u00e9s ajout\u00e9s dans de nombreux aliments transform\u00e9s afin d'en am\u00e9liorer la texture et d'en prolonger la dur\u00e9e de conservation. Ils ont \u00e9t\u00e9 r\u00e9cemment identifi\u00e9s comme alt\u00e9rant n\u00e9gativement le microbiote intestinal, pouvant conduire au d\u00e9veloppement d\u2019inflammations intestinales.<\/p>\r\n<p style=\"text-align: justify;\">Il a \u00e9galement \u00e9t\u00e9 observ\u00e9 que les souris colonis\u00e9es par un microbiote de faible complexit\u00e9 \u00e9taient prot\u00e9g\u00e9es contre les effets n\u00e9gatifs de certains \u00e9mulsifiants. Ces observations ant\u00e9rieures ont conduit les chercheurs \u00e0 \u00e9mettre l'hypoth\u00e8se que les \u00e9mulsifiants pourraient stimuler certaines bact\u00e9ries sp\u00e9cifiques, tels que certains\u00a0<strong>pathobiontes<\/strong>, des bact\u00e9ries ayant un potentiel pathog\u00e8ne mais inoffensives dans des conditions \"normales\". Ces derni\u00e8res, en pr\u00e9sence d\u2019agents \u00e9mulsifiants, seraient-elles capables de favoriser le d\u00e9veloppement d'inflammation intestinale chronique et de maladies associ\u00e9es, telles que le cancer du c\u00f4lon\u00a0?<\/p>\r\n<h3 style=\"text-align: justify;\">Les r\u00e9sultats<\/h3>\r\n<p style=\"text-align: justify;\">Afin de tester cette hypoth\u00e8se, les chercheurs ont colonis\u00e9 deux mod\u00e8les murins diff\u00e9rents, l\u2019un ax\u00e9nique (sans microbiote), l\u2019autre ASF (avec un microbiote minimal comprenant seulement 8 esp\u00e8ces) par une souche de la bact\u00e9rie Escherichia coli adh\u00e9rente et invasive (AIEC), associ\u00e9es \u00e0 la maladie\u00a0de Crohn. Ils ont ensuite administr\u00e9 un \u00e9mulsifiant, soit de la carboxym\u00e9thylcellulose (CMC - E466) ou du polysorbate 80 (P80 - E433).<\/p>\r\n<p style=\"text-align: justify;\">Alors que la seule consommation d\u2019agents \u00e9mulsifiants \u00e9tait inoffensive chez les souris ax\u00e9niques ou ASF, une colonisation par les bact\u00e9ries AIEC combin\u00e9e \u00e0 ces agents entra\u00eenait le d\u00e9veloppement d'une inflammation intestinale chronique et de d\u00e9r\u00e9gulations m\u00e9taboliques. De plus, la colonisation par les bact\u00e9ries AIEC entra\u00eene une inflammation intestinale s\u00e9v\u00e8re et une exacerbation du cancer colorectal en r\u00e9ponse \u00e0 la consommation d'\u00e9mulsifiants dans des mod\u00e8les animaux de ces deux maladies.<\/p>\r\n<p style=\"text-align: justify;\">Des approches in vitro ont d\u00e9montr\u00e9 que l'exposition aux \u00e9mulsifiants augmentait la motilit\u00e9 des bact\u00e9ries AIEC et leur capacit\u00e9 \u00e0 adh\u00e9rer aux cellules \u00e9pith\u00e9liales intestinales. Une analyse du transcriptome (tous les ARNm) des bact\u00e9ries AIEC trait\u00e9es par les \u00e9mulsifiants a r\u00e9v\u00e9l\u00e9 que ces compos\u00e9s induisaient l'expression de groupes de g\u00e8nes impliqu\u00e9s dans la virulence de cette bact\u00e9rie et dans sa propension \u00e0 induire l\u2019inflammation. Nous avons ainsi pu identifier un m\u00e9canisme par lequel les \u00e9mulsifiants alimentaires pouvaient favoriser l'inflammation intestinale chronique chez les personnes abritant certains pathobiontes dans leur tractus digestif.<\/p>\r\n<p><a href=\"https:\/\/cri1149.fr\/publications\/dietary-emulsifiers-directly-impact-adherentinvasive-e-coli-gene-expression-to-drive-chronic-intestinal-inflammation\/attachment\/fig-emulsifiants-ic-cri\/\" rel=\"attachment wp-att-16055\"><img class=\"aligncenter  wp-image-16055\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/10\/fig-emulsifiants-ic-cri-232x300.jpg\" alt=\"\" width=\"390\" height=\"505\" \/><\/a><\/p>\r\n<h3 style=\"text-align: justify;\">Les perspectives<\/h3>\r\n<p style=\"text-align: justify;\">Cette \u00e9tude d\u00e9montre que certains \u00e9mulsifiants alimentaires stimulent la virulence de certains pathobiontes, permettant ainsi d\u2019identifier un m\u00e9canisme par lequel ces compos\u00e9s peuvent provoquer une inflammation chez les individus porteurs de ces bact\u00e9ries. Ces r\u00e9sultats r\u00e9v\u00e8lent \u00e9galement que les deux agents \u00e9mulsifiants test\u00e9s n'agissent pas de la m\u00eame mani\u00e8re sur ces pathobiontes, sugg\u00e9rant qu'ils pourraient avoir un effet synergique n\u00e9faste lorsqu'ils sont combin\u00e9s, comme c'est souvent le cas dans les aliments transform\u00e9s.<\/p>\r\n<p style=\"text-align: justify;\">Les AIEC sont probablement un exemple parmi d'autres de pathobiontes pouvant m\u00e9dier les effets nocifs des \u00e9mulsifiants, et l'identification d'autres bact\u00e9ries sensibles \u00e0 ces additifs est maintenant requise.<\/p>\r\n<p style=\"text-align: justify;\">N\u00e9anmoins, ces r\u00e9sultats sugg\u00e8rent qu\u2019une intervention alimentaire bas\u00e9e sur le microbiote pourrait \u00eatre un moyen efficace pour la gestion des maladies inflammatoires chroniques de l'intestin. Ainsi, des personnes porteuses de\u00a0microbiotes sp\u00e9cifiques et susceptibles b\u00e9n\u00e9ficieraient grandement de recommandations alimentaires cibl\u00e9es proposant, par exemple, l\u2019\u00e9viction de ces agents \u00e9mulsifiants.<\/p>\r\n<p style=\"text-align: justify;\"><em>Ce travail a \u00e9t\u00e9 soutenu par la Kenneth Rainin Foundation. De plus, Emilie Viennois est r\u00e9cipiendaire d\u2019un prix \u00ab\u00a0Career Development\u00a0\u00bb de la Crohn\u2019s and Colitis Foundation (CCF) et d\u2019une bourse Marie Sklodowska-Curie de la Commission Europ\u00e9enne. Benoit Chassaing. est soutenu par un \u201cERC Starting Grant\u201d du Conseil europ\u00e9en de la Recherche, une Chaire d\u2019Excellence de Universit\u00e9 de Paris et un prix \u00ab\u00a0Career Development\u00a0\u00bb de la CCF.<\/em><\/p>\r\n<p style=\"text-align: justify;\">\u00a0<\/p>\r\n<p>http:\/\/www.idf.inserm.fr\/actualites\/emulsifiants-alimentaires-et-microbiote-des-liens-dans-l-inflammation-intestinale-chronique<\/p>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/dietary-emulsifiers-directly-impact-adherentinvasive-e-coli-gene-expression-to-drive-chronic-intestinal-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation - 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