{"id":15813,"date":"2020-08-19T16:34:47","date_gmt":"2020-08-19T14:34:47","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&p=15813"},"modified":"2025-09-11T16:48:01","modified_gmt":"2025-09-11T14:48:01","slug":"microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c\/","title":{"rendered":"MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-15813","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Scientific Reports","date_de_publication":"20161012","numero_doi":"","equipe":[130],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Kevin Appourchaux[:]"},{"texte_libre":false,"auteur-lien":15808,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Matthieu Resche-Rigon[:]"},{"texte_libre":false,"auteur-lien":13160,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Martine Lapalus[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Charles-Henry Gattolliat[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Emmanuelle Porchet[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Michelle Martinot-Peignoux[:]"},{"texte_libre":false,"auteur-lien":13044,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Michel Vidaud[:]"},{"texte_libre":false,"auteur-lien":13027,"auteur-text":""},{"texte_libre":false,"auteur-lien":13117,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Ivan Bi\u00e8che[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Emilie Estrabaud[:]"},{"texte_libre":false,"auteur-lien":13023,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/srep34935"}],"paragraphe":"

Abstract<\/h2>\r\n
\r\n

Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with chronic hepatitis B (CHB) and C (CHC). The expression of 13 fibrosis-related microRNAs (miRNAs) (miR-20a, miR-21, miR-27a, miR-27b, miR-29a, miR-29c, miR-92a, miR-122, miR-146a, miR-155, miR-221, miR-222, and miR-224) was analyzed in 194 serums and 177 liver biopsies of patients with either CHB or CHC to develop models to diagnose advanced fibrosis and cirrhosis (Metavir F3-F4). In CHB patients, the model (serum miR-122, serum miR-222, platelet count and alkaline phosphatase) was more accurate than APRI and FIB-4 to discriminate in between mild and moderate fibrosis (F1-F2) and F3-F4 (AUC of CHB model: 0.85 vs APRI: 0.70 and FIB-4: 0.81). In CHC patients, the model (hepatic miR-122, hepatic miR-224, platelet count, albumin and alanine aminotransferase) was more accurate than both APRI and FIB-4 to discriminate in between patients with F3-F4 and F1-F2 (AUC of the CHC model\u2009=\u20090.93 vs APRI: 0.86 and FIB-4: 0.79). Most of the miRNAs tested were differentially expressed in patients with CHB and CHC. In particular, serum miR-122 was 28-fold higher in patients with CHB than in those with CHC. Both CHB and CHC models may help for the diagnosis of advanced fibrosis and cirrhosis (F3-F4).<\/p>\r\n<\/div>","paragraphe_en":"

Abstract<\/h2>\r\n
\r\n

Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with chronic hepatitis B (CHB) and C (CHC). The expression of 13 fibrosis-related microRNAs (miRNAs) (miR-20a, miR-21, miR-27a, miR-27b, miR-29a, miR-29c, miR-92a, miR-122, miR-146a, miR-155, miR-221, miR-222, and miR-224) was analyzed in 194 serums and 177 liver biopsies of patients with either CHB or CHC to develop models to diagnose advanced fibrosis and cirrhosis (Metavir F3-F4). In CHB patients, the model (serum miR-122, serum miR-222, platelet count and alkaline phosphatase) was more accurate than APRI and FIB-4 to discriminate in between mild and moderate fibrosis (F1-F2) and F3-F4 (AUC of CHB model: 0.85 vs APRI: 0.70 and FIB-4: 0.81). In CHC patients, the model (hepatic miR-122, hepatic miR-224, platelet count, albumin and alanine aminotransferase) was more accurate than both APRI and FIB-4 to discriminate in between patients with F3-F4 and F1-F2 (AUC of the CHC model\u2009=\u20090.93 vs APRI: 0.86 and FIB-4: 0.79). Most of the miRNAs tested were differentially expressed in patients with CHB and CHC. In particular, serum miR-122 was 28-fold higher in patients with CHB than in those with CHC. Both CHB and CHC models may help for the diagnosis of advanced fibrosis and cirrhosis (F3-F4).<\/p>\r\n<\/div>","documents":null},"yoast_head":"\nMicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/microrna-based-diagnostic-tools-for-advanced-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b-and-c\\\/\",\"name\":\"MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C - 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