{"id":14981,"date":"2019-11-07T14:09:02","date_gmt":"2019-11-07T13:09:02","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=14981"},"modified":"2025-09-11T16:48:02","modified_gmt":"2025-09-11T14:48:02","slug":"iga1-protease-treatment-reverses-mesangial-deposits-and-hematuria-in-a-model-of-iga-nephropathy","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/iga1-protease-treatment-reverses-mesangial-deposits-and-hematuria-in-a-model-of-iga-nephropathy\/","title":{"rendered":"IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-14981","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Am Soc Nephrol.","date_de_publication":"20160901","numero_doi":"","equipe":[138],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lechner SM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Abbad L"},{"texte_libre":false,"auteur-lien":13038,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Papista C"},{"texte_libre":false,"auteur-lien":13218,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Moal C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maillard J"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jamin A"},{"texte_libre":false,"auteur-lien":13036,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Wang Y"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Li A"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Martini PG"},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Berthelot L."}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26850635"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">IgA nephropathy (IgAN), characterized by mesangial IgA1 deposits, is a leading cause of renal failure worldwide. IgAN pathogenesis involves circulating hypogalactosylated IgA1 complexed with soluble IgA Fc receptor I (sCD89) and\/or anti-hypogalactosylated-IgA1 autoantibodies, but no specific treatment is available for IgAN. The absence of IgA1 and CD89 homologs in the mouse has precluded in\u00a0vivo proof-of-concept studies of specific therapies targeting IgA1. However, the \u03b11KI\u2011CD89Tg mouse model of IgAN, which expresses human IgA1 and human CD89, allows in\u00a0vivo testing of recombinant IgA1 protease (IgA1\u2011P), a bacterial protein that selectively cleaves human IgA1. Mice injected with IgA1\u2011P (1-10\u00a0mg\/kg) had Fc fragments of IgA1 in both serum and urine, associated with a decrease in IgA1-sCD89 complexes. Levels of mesangial IgA1 deposits and the binding partners of these deposits (sCD89, transferrin receptor, and transglutaminase\u00a02) decreased markedly 1\u00a0week after treatment, as did the levels of C3 deposition, CD11b(+) infiltrating cells, and fibronectin. Antiprotease antibodies did not significantly alter IgA1\u2011P activity. Moreover, hematuria consistently decreased after treatment. In conclusion, IgA1\u2011P strongly diminishes human IgA1 mesangial deposits and reduces inflammation, fibrosis, and hematuria in a mouse IgAN model, and therefore may be a plausible treatment for patients with IgAN.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/iga1-protease-treatment-reverses-mesangial-deposits-and-hematuria-in-a-model-of-iga-nephropathy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy. - 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