{"id":14980,"date":"2019-11-07T14:04:29","date_gmt":"2019-11-07T13:04:29","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=14980"},"modified":"2025-09-11T16:48:02","modified_gmt":"2025-09-11T14:48:02","slug":"serum-iron-protects-from-renal-postischemic-injury","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/serum-iron-protects-from-renal-postischemic-injury\/","title":{"rendered":"Serum Iron Protects from Renal Postischemic Injury."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-14980","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Am Soc Nephrol.","date_de_publication":"20171201","numero_doi":"","equipe":[138],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Vaugier C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Amano MT"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Chemouny JM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Dussiot M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Berrou C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matignon M"},{"texte_libre":false,"auteur-lien":13033,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Wang PHM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fricot A"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maciel TT"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Grapton D"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mathieu JRR"},{"texte_libre":false,"auteur-lien":13026,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Peraldi MN"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Peyssonnaux C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mesnard L"},{"texte_libre":false,"auteur-lien":13058,"auteur-text":""},{"texte_libre":false,"auteur-lien":13168,"auteur-text":""},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Hermine O"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ginzburg YZ"},{"texte_libre":false,"auteur-lien":13030,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Camara NOS"},{"texte_libre":false,"auteur-lien":13075,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Moura IC"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28784700"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury. In a retrospective cohort study of renal allograft recipients (<i>n<\/i>=169), increased baseline levels of serum ferritin reliably predicted a positive outcome for allografts, particularly in elderly patients. In mice, systemic iron overload protected against renal ischemia-reperfusion injury-associated sterile inflammation. Furthermore, chronic iron injection in mice prevented macrophage recruitment after inflammatory stimuli. Macrophages cultured in high-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, increased expression of the NRF2-related antioxidant response genes, and limited NF-<i>\u03ba<\/i>B and proinflammatory signaling. In macrophage-depleted animals, the infusion of macrophages cultured in high-iron conditions did not reconstitute AKI after ischemia-reperfusion, whereas macrophages cultured in physiologic iron conditions did. These findings identify serum iron as a critical protective factor in renal allograft outcome. Increasing serum iron levels in patients may thus improve prognosis of renal transplants.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Serum Iron Protects from Renal Postischemic Injury. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/serum-iron-protects-from-renal-postischemic-injury\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Serum Iron Protects from Renal Postischemic Injury. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/serum-iron-protects-from-renal-postischemic-injury\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:02+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/serum-iron-protects-from-renal-postischemic-injury\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/serum-iron-protects-from-renal-postischemic-injury\\\/\",\"name\":\"Serum Iron Protects from Renal Postischemic Injury. - 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