{"id":14600,"date":"2019-10-10T21:42:38","date_gmt":"2019-10-10T20:42:38","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&p=14600"},"modified":"2025-09-11T16:48:03","modified_gmt":"2025-09-11T14:48:03","slug":"characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction\/","title":{"rendered":"Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-14600","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Physiol. 2018 Jul 24;9:980","date_de_publication":"20180724","numero_doi":"","equipe":[],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fernandez N"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Wrzosek L"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Radziwill-Bienkowska JM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ringot-Destrez B"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Duviau MP"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Noordine ML"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Laroute V"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Robert V"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cherbuy C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Daveran-Mingot ML"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cocaign-Bousquet M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"L\u00e9onard R"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Robbe-Masselot C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rul F"},{"texte_libre":false,"auteur-lien":13131,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thomas M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mercier-Bonin M"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6067005\/"}],"paragraphe":"

Abstract<\/h2>\r\n
\r\n

Mucus is a major component of the intestinal barrier involved both in the protection of the host and the fitness of commensals of the gut.\u00a0Streptococcus thermophilus<\/em>\u00a0is consumed world-wide in fermented dairy products and is also recognized as a probiotic, as its consumption is associated with improved lactose digestion. We determined the overall effect of\u00a0S. thermophilus<\/em>\u00a0on the mucus by evaluating its ability to adhere, degrade, modify, or induce the production of mucus and\/or mucins. Adhesion was analyzed\u00a0in vitro<\/em>\u00a0using two types of mucins (from pig or human biopsies) and mucus-producing intestinal HT29-MTX cells. The induction of mucus was characterized in two different rodent models, in which\u00a0S. thermophilus<\/em>\u00a0is the unique bacterial species in the digestive tract or transited as a sub-dominant bacterium through a complex microbiota.\u00a0S. thermophilus<\/em>\u00a0LMD-9 and LMG18311 strains did not grow in sugars used to form mucins as the sole carbon source and displayed weak binding to mucus\/mucins relative to the highly adhesive TIL448\u00a0Lactococcus lactis<\/em>. The presence of\u00a0S. thermophilus<\/em>\u00a0as the unique bacteria in the digestive tract of gnotobiotic rats led to accumulation of lactate and increased the number of Alcian-Blue positive goblet cells and the amount of the mucus-inducer KLF4 transcription factor. Lactate significantly increased KLF4 protein levels in HT29-MTX cells. Introduction of\u00a0S. thermophilus<\/em>\u00a0via<\/em>\u00a0transit as a sub-dominant bacterium (103<\/sup>\u00a0CFU\/g feces) in a complex endogenous microbiota resulted in a slight increase in lactate levels in the digestive tract, no induction of overall mucus production, and moderate induction of sulfated mucin production. We thus show that although\u00a0S. thermophilus<\/em>\u00a0is a poor mucus-adhesive bacterium, it can promote mucus pathway at least in part by producing lactate in the digestive tract.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"\nCharacterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/characterization-of-mucus-related-properties-of-streptococcus-thermophilus-from-adhesion-to-induction\\\/\",\"name\":\"Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction - 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