{"id":14598,"date":"2019-10-10T21:29:34","date_gmt":"2019-10-10T20:29:34","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=14598"},"modified":"2025-09-11T16:48:03","modified_gmt":"2025-09-11T14:48:03","slug":"ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a\/","title":{"rendered":"Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-14598","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"[:fr]Biochim Biophys Acta Mol Basis Dis.[:en]Biochim Biophys Acta Mol Basis Dis. [:]","date_de_publication":"20180818","numero_doi":"","equipe":[121],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Messal N"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fernandez N"},{"texte_libre":false,"auteur-lien":13257,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13082,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13130,"auteur-text":[]},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Prochasson C"},{"texte_libre":false,"auteur-lien":13050,"auteur-text":[]},{"texte_libre":true,"auteur-lien":null,"auteur-text":"LeGuilloux G"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jarry A"},{"texte_libre":false,"auteur-lien":13054,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13160,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13167,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13131,"auteur-text":[]},{"texte_libre":false,"auteur-lien":13053,"auteur-text":[]}],"auteurs-manuel":"Messal N, Fernandez N, Dayot S, Gratio V, Nicole P, Prochasson C, Chantret I, LeGuilloux G, Jarry A, Couvelard A, Tr\u00e9ton X, Voisin T, Ogier-Denis E, Couvineau A.","liens_externes":null,"liens":[{"lien":"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0925443918303168?via%3Dihub"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">Orexins (orexin-A and orexin-B) are hypothalamic peptides that are produced by the same precursor and are involved in sleep\/wake control, which is mediated by two G protein-coupled receptor subtypes, OX1R and OX2R. Ulcerative colitis (UC) is an inflammatory bowel disease, (IBD) which is characterized by long-lasting inflammation and ulcers that affect the colon and rectum mucosa and is known to be a significant risk factor for colon cancer development. Based on our recent studies showing that OX1R is aberrantly expressed in colon cancer, we wondered whether orexin-A could play a role in UC. Immunohistochemistry studies revealed that OX1R is highly expressed in the affected colonic epithelium of most UC patients, but not in the non-affected colonic mucosa. Injection of exogenous orexin-A specifically improved the inflammatory symptoms in the two colitis murine models. Conversely, injection of inactive orexin-A analog, OxB7-28 or OX1R specific antagonist SB-408124 did not have anti-inflammatory effect. Moreover, treatment with orexin-A in DSS-colitis induced OX1R<sup>-\/-<\/sup>\u00a0knockout mice did not have any protective effect. The orexin-A anti-inflammatory effect was due to the decreased expression of pro-inflammatory cytokines in immune cells and specifically in T-cells isolated from colonic mucosa. Moreover, orexin-A inhibited canonical NF\u03baB activation in an immune cell line and in intestinal epithelial cell line. These results suggest that orexin-A might represent a promising alternative to current UC therapies.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/ectopic-expression-of-ox1r-in-ulcerative-colitis-mediates-anti-inflammatory-effect-of-orexin-a\\\/\",\"name\":\"Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. - 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