{"id":13412,"date":"2019-03-14T15:15:34","date_gmt":"2019-03-14T14:15:34","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13412"},"modified":"2025-09-11T16:48:03","modified_gmt":"2025-09-11T14:48:03","slug":"lyn-and-fyn-function-as-molecular-switches-that-control-antigen-receptors-directing-homeostasis-or-inflammation","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/lyn-and-fyn-function-as-molecular-switches-that-control-antigen-receptors-directing-homeostasis-or-inflammation\/","title":{"rendered":"Lyn and Fyn function as molecular switches that control antigen receptors directing homeostasis or inflammation"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13412","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Nat Comm, in press.","date_de_publication":"20170815","numero_doi":"","equipe":[138],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13033,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Murua Amaya"},{"texte_libre":false,"auteur-lien":13074,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Titeca Dimitri"},{"texte_libre":false,"auteur-lien":13179,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Danelli Luca"},{"texte_libre":false,"auteur-lien":13098,"auteur-text":""},{"texte_libre":false,"auteur-lien":13030,"auteur-text":""},{"texte_libre":false,"auteur-lien":13037,"auteur-text":""},{"texte_libre":false,"auteur-lien":13058,"auteur-text":""},{"texte_libre":false,"auteur-lien":13051,"auteur-text":""},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/s41467-017-00294-0"}],"paragraphe":"<h2 id=\"Abs1\" class=\"c-article-section__title u-h2 js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">Immunoreceptors can transduce either inhibitory or activatory signals depending on ligand avidity and phosphorylation status, which is modulated by the protein kinases Lyn and Fyn. Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the immunoreceptor. By contrast, Fyn-dependent phosphorylation of SHP-1 serine 591 inactivates the phosphatase, enabling activatory immunoreceptor signaling. These SHP-1 signatures are relevant in vivo, as Lyn deficiency exacerbates nephritis and arthritis in mice, whereas Fyn deficiency is protective. Similarly, Fyn-activating signature is detected in patients with lupus nephritis, underlining the importance of this Lyn\u2013Fyn balance. These data show how receptors discriminate negative from positive signals that respectively result in homeostatic or inflammatory conditions.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lyn and Fyn function as molecular switches that control antigen receptors directing homeostasis or inflammation - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/lyn-and-fyn-function-as-molecular-switches-that-control-antigen-receptors-directing-homeostasis-or-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lyn and Fyn function as molecular switches that control antigen receptors directing homeostasis or inflammation - 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