{"id":13404,"date":"2019-03-13T17:59:23","date_gmt":"2019-03-13T16:59:23","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13404"},"modified":"2025-09-11T16:48:03","modified_gmt":"2025-09-11T14:48:03","slug":"microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome\/","title":{"rendered":"Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13404","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Physiol","date_de_publication":"20170419","numero_doi":"10.3389\/fphys.2017.00224","equipe":[131],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Laura Gillard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Camille Mayeur "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"V\u00e9ronique Robert"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Isabelle Pingenot"},{"texte_libre":false,"auteur-lien":13100,"auteur-text":""},{"texte_libre":false,"auteur-lien":13025,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Patricia Lepage"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Muriel Thomas"},{"texte_libre":false,"auteur-lien":13091,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/28469580\/"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, a low amount of some anaerobic microbes (<i>Clostridium leptum<\/i>) and an accumulation of fecal lactate in some patients. Patients with jejuno-colonic anastomosis were stratified according to the presence of lactate in their feces and, we observe that the lactate-producing bacteria were predominant in the sub-group of patients accumulating fecal lactate. One case of D-encephalopathy crisis occurred when the D-lactate isoform accumulated in the feces and plasma bicarbonate levels decreased. The fecal sample at the time of the encephalopathy was transferred to germ free rats (SBS-H rats). The SBS-H microbiota conserved some characteristics of the SBS donnor, predominated by lactate-producing bacteria (mainly\u00a0<i>Lactobacillus<\/i>), a low level of lactate-consuming bacteria and undetectable\u00a0<i>C. leptum<\/i>. However, lactate did not accumulate in feces of recipient rats and the D-encephalopathy was not reproduced in SBS-H rats. This suggests that the intact small bowel of the recipient rats protected them from lactate accumulation and that D-lactate encephalopathy can occur only in the absence of small intestine. After fecal transfer, we also show that gnotobiotic rats exhibited high levels of circulating GLP-1 and ghrelin, two hormones that are known to be induced in SBS patients. Therefore, the microbiota of SBS is a reservoir of biological signals involved in post-resection adaptation.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/microbiota-is-involved-in-post-resection-adaptation-in-humans-with-short-bowel-syndrome\\\/\",\"name\":\"Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome. - 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