{"id":13395,"date":"2019-03-13T17:17:17","date_gmt":"2019-03-13T16:17:17","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13395"},"modified":"2025-12-03T18:04:08","modified_gmt":"2025-12-03T17:04:08","slug":"yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling\/","title":{"rendered":"Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13395","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Clin Invest.","date_de_publication":"20120508","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jung C"},{"texte_libre":false,"auteur-lien":13118,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Montcuquet N"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thachil E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ch\u00e2teau D"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thi\u00e9baut R"},{"texte_libre":false,"auteur-lien":13149,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alnabhani Z"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Berrebi D"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Dussaillant M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pedruzzi E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thenet S"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cerf-Bensussan N"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Barreau F"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22565313"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Intestinal barrier function requires intricate cooperation between intestinal epithelial cells and immune cells. Enteropathogens are able to invade the intestinal lymphoid tissue known as Peyer's patches (PPs) and disrupt the integrity of the intestinal barrier. However, the underlying molecular mechanisms of this process are poorly understood. In mice infected with Yersinia pseudotuberculosis, we found that PP barrier dysfunction is dependent on the Yersinia virulence plasmid and the expression of TLR-2 by hematopoietic cells, but not by intestinal epithelial cells. Upon TLR-2 stimulation, Y. pseudotuberculosis-infected monocytes activated caspase-1 and produced IL-1\u03b2. In turn, IL-1\u03b2 increased NF-\u03baB and myosin light chain kinase activation in intestinal epithelial cells, thus disrupting the intestinal barrier by opening the tight junctions. Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the interplay between immune and epithelial cells during infection.<\/p>\r\n<\/div>","paragraphe_en":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Intestinal barrier function requires intricate cooperation between intestinal epithelial cells and immune cells. Enteropathogens are able to invade the intestinal lymphoid tissue known as Peyer's patches (PPs) and disrupt the integrity of the intestinal barrier. However, the underlying molecular mechanisms of this process are poorly understood. In mice infected with Yersinia pseudotuberculosis, we found that PP barrier dysfunction is dependent on the Yersinia virulence plasmid and the expression of TLR-2 by hematopoietic cells, but not by intestinal epithelial cells. Upon TLR-2 stimulation, Y. pseudotuberculosis-infected monocytes activated caspase-1 and produced IL-1\u03b2. In turn, IL-1\u03b2 increased NF-\u03baB and myosin light chain kinase activation in intestinal epithelial cells, thus disrupting the intestinal barrier by opening the tight junctions. Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the interplay between immune and epithelial cells during infection.<\/p>\r\n<\/div>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-03T17:04:08+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/yersinia-pseudotuberculosis-disrupts-intestinal-barrier-integrity-through-hematopoietic-tlr-2-signaling\/\",\"name\":\"Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling - 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