{"id":13394,"date":"2019-03-13T15:00:11","date_gmt":"2019-03-13T14:00:11","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&p=13394"},"modified":"2025-09-11T16:48:04","modified_gmt":"2025-09-11T14:48:04","slug":"abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease\/","title":{"rendered":"Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn\u2019s Disease Short title: Crinophagy in Crohn\u2019s disease"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13394","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Gastroenterology.","date_de_publication":"20120501","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thachil E"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Arbeille B"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Paris R"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Grodet A"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Peuchmaur M"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Codogno P"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Barreau F"},{"texte_libre":false,"auteur-lien":13131,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Berrebi D"},{"texte_libre":false,"auteur-lien":13164,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22285936"}],"paragraphe":"","paragraphe_en":"

Abstract<\/h2>\r\n
\r\n

Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD). However, little is known about the role of autophagy in CD. Intestinal biopsies from untreated pediatric patients with CD, celiac disease, or ulcerative colitis were analyzed by immunohistochemistry and electron microscopy. We observed that autophagy was specifically activated in Paneth cells from patients with CD, independently of mucosal inflammation or disease-associated variants of ATG16L1 or IRGM. In these cells, activation of autophagy was associated with a significant decrease in number of secretory granules and features of crinophagy. These observations might account for the disorganization of secretory granules previously reported in Paneth cells from patients with CD.<\/p>\r\n<\/div>","documents":null},"yoast_head":"\nAbnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn\u2019s Disease Short title: Crinophagy in Crohn\u2019s disease - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn\u2019s Disease Short title: Crinophagy in Crohn\u2019s disease - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/abnormal-activation-of-autophagy-induced-crinophagy-in-paneth-cells-from-patients-with-crohns-disease-short-title-crinophagy-in-crohns-disease\\\/\",\"name\":\"Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn\u2019s Disease Short title: Crinophagy in Crohn\u2019s disease - 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