{"id":13386,"date":"2019-03-13T14:29:42","date_gmt":"2019-03-13T13:29:42","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13386"},"modified":"2025-09-11T16:48:04","modified_gmt":"2025-09-11T14:48:04","slug":"nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions\/","title":{"rendered":"NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13386","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Mucosal Immunology.","date_de_publication":"20181002","numero_doi":"","equipe":[133],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Makhezer N"},{"texte_libre":false,"auteur-lien":13210,"auteur-text":""},{"texte_libre":false,"auteur-lien":13249,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Khichane Y"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marzaioli V"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Tlili A"},{"texte_libre":false,"auteur-lien":13251,"auteur-text":""},{"texte_libre":false,"auteur-lien":13174,"auteur-text":""},{"texte_libre":false,"auteur-lien":13106,"auteur-text":""},{"texte_libre":false,"auteur-lien":13089,"auteur-text":""},{"texte_libre":false,"auteur-lien":13071,"auteur-text":""},{"texte_libre":false,"auteur-lien":14856,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sannier A"},{"texte_libre":false,"auteur-lien":13138,"auteur-text":""},{"texte_libre":false,"auteur-lien":13057,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/s41385-018-0086-4"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\">Inflammatory bowel disease (IBD) is characterized by severe and recurrent inflammation of the gastrointestinal tract, associated with altered patterns of cytokine synthesis, excessive reactive oxygen species (ROS) production, and high levels of the innate immune protein, lipocalin-2 (LCN-2), in the mucosa. The major source of ROS in intestinal epithelial cells is the NADPH oxidase NOX1, which consists of the transmembrane proteins, NOX1 and p22<sup>PHOX<\/sup>, and the cytosolic proteins, NOXO1, NOXA1, and Rac1. Here, we investigated whether NOX1 activation and ROS production induced by key inflammatory cytokines in IBD causally affects LCN-2 production in colonic epithelial cells. We found that the combination of TNF\u03b1 and IL-17 induced a dramatic upregulation of NOXO1 expression that was dependent on the activation of p38MAPK and JNK1\/2, and resulted into an increase of NOX1 activity and ROS production. NOX1-derived ROS drive the expression of LCN-2 by controlling the expression of I\u03baB\u03b6, a master inducer of LCN-2. Furthermore, LCN-2 production and colon damage were decreased in NOX1-deficient mice during TNBS-induced colitis. Finally, analyses of biopsies from patients with Crohn's disease showed increased JNK1\/2 activation, and NOXO1 and LCN-2 expression. Therefore, NOX1 might play a key role in mucosal immunity and inflammation by controlling LCN-2 expression.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/nox1-derived-ros-drive-the-expression-of-lipocalin-2-in-colonic-epithelial-cells-in-inflammatory-conditions\/\",\"name\":\"NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions - 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