{"id":13375,"date":"2019-03-13T11:38:21","date_gmt":"2019-03-13T10:38:21","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&p=13375"},"modified":"2025-09-11T16:48:04","modified_gmt":"2025-09-11T14:48:04","slug":"abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis\/","title":{"rendered":"Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13375","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Gastroenterology.","date_de_publication":"20120330","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bresson J"},{"texte_libre":true,"auteur-lien":null,"auteur-text":" Sainte-Marie Y"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Vion AC"},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Renard JM"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Devue C"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Heymes C"},{"texte_libre":false,"auteur-lien":13106,"auteur-text":""},{"texte_libre":false,"auteur-lien":14888,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lebrec D"},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Tedgui A"},{"texte_libre":false,"auteur-lien":13124,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Boulanger CM"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22465620"}],"paragraphe":"

Abstract<\/h3>\r\n
\r\n

BACKGROUND & AIMS:<\/h4>\r\n

Circulating membrane-shed\u00a0microparticles<\/span>\u00a0(MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in\u00a0plasma<\/span>\u00a0from\u00a0patients<\/span>\u00a0with\u00a0cirrhosis<\/span>\u00a0and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension.<\/p>\r\n

METHODS:<\/h4>\r\n

We analyzed MPs from blood samples of 91\u00a0patients<\/span>\u00a0with\u00a0cirrhosis<\/span>\u00a0and 30 healthy individuals (controls) using flow cytometry; their effects on the vascular response to vasoconstrictors were examined in vitro and in vivo.<\/p>\r\n

RESULTS:<\/h4>\r\n

Circulating levels of leuko-endothelial (CD31(+)\/41(-)), pan-leukocyte (CD11a(+)), lymphocyte (CD4(+)), and erythrocyte (CD235a(+)) MPs were higher in\u00a0patients<\/span>\u00a0with\u00a0cirrhosis<\/span>\u00a0than in controls.\u00a0Plasma<\/span>\u00a0of\u00a0patients<\/span>\u00a0with\u00a0cirrhosis<\/span>\u00a0contained hepatocyte-derived MPs (cytokeratin-18(+)), whereas\u00a0plasma<\/span>\u00a0from controls did not. The severity of\u00a0cirrhosis<\/span>\u00a0and systemic inflammation were major determinants of the levels of leuko-endothelial and hepatocyte MPs. MPs from\u00a0patients<\/span>\u00a0with advanced\u00a0cirrhosis<\/span>\u00a0significantly impaired contraction of vessels in response to phenylephrine, whereas MPs from healthy controls or from\u00a0patients<\/span>\u00a0of Child-Pugh class A did not. This effect depended on cyclooxygenase type 1 and required phosphatidylserine on the surface of MPs. Intravenous injection of MPs from\u00a0patients<\/span>\u00a0with\u00a0cirrhosis<\/span>\u00a0into BALB\/C mice decreased mean arterial blood pressure.<\/p>\r\n

CONCLUSIONS:<\/h4>\r\n

Cirrhosis<\/span>\u00a0is associated with increases in circulating subpopulations of MPs, likely resulting from systemic inflammation and liver cell damage. The overall pool of circulating MPs from\u00a0patients<\/span>\u00a0with advanced\u00a0cirrhosis<\/span>\u00a0impairs\u00a0vasoconstrictor<\/span>\u00a0responses<\/span>\u00a0and decreases blood pressure, contributing to the arterial vasodilation associated with portal hypertension.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"\nAbnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/abnormal-plasma-microparticles-impair-vasoconstrictor-responses-in-patients-with-cirrhosis\/\",\"name\":\"Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis. - 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