{"id":13372,"date":"2019-03-13T11:21:03","date_gmt":"2019-03-13T10:21:03","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&#038;p=13372"},"modified":"2025-09-11T16:48:04","modified_gmt":"2025-09-11T14:48:04","slug":"liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases\/","title":{"rendered":"Liver sinusoidal endothelial cells: physiology and role in liver diseases"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13372","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Hepatol.","date_de_publication":"20170104","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13246,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lemoinne S"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Boulanger C"},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":false,"auteur-lien":13124,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27423426"}],"paragraphe":"<h3 style=\"text-align: justify;\">Abstract<\/h3>\r\n<div class=\"\">\r\n<p style=\"text-align: justify;\"><span class=\"highlight\">Liver<\/span>\u00a0<span class=\"highlight\">sinusoidal<\/span>\u00a0<span class=\"highlight\">endothelial cells<\/span>\u00a0(LSECs) are highly specialized\u00a0<span class=\"highlight\">endothelial cells<\/span>\u00a0representing the interface between blood\u00a0<span class=\"highlight\">cells<\/span>\u00a0on the one side and hepatocytes and hepatic stellate\u00a0<span class=\"highlight\">cells<\/span>\u00a0on the other side. LSECs represent a permeable barrier. Indeed, the association of 'fenestrae', absence of diaphragm and lack of basement membrane make them the most permeable\u00a0<span class=\"highlight\">endothelial cells<\/span>\u00a0of the mammalian body. They also have the highest endocytosis capacity of human\u00a0<span class=\"highlight\">cells<\/span>. In physiological conditions, LSECs regulate hepatic vascular tone contributing to the maintenance of a low portal pressure despite the major changes in hepatic blood flow occurring during digestion. LSECs maintain hepatic stellate cell quiescence, thus inhibiting intrahepatic vasoconstriction and fibrosis development. In pathological conditions, LSECs play a key\u00a0<span class=\"highlight\">role<\/span>\u00a0in the initiation and progression of chronic\u00a0<span class=\"highlight\">liver diseases<\/span>. Indeed, they become capillarized and lose their protective properties, and they promote angiogenesis and vasoconstriction. LSECs are implicated in\u00a0<span class=\"highlight\">liver<\/span>\u00a0regeneration following acute\u00a0<span class=\"highlight\">liver<\/span>\u00a0injury or partial hepatectomy since they renew from LSECs and\/or LSEC progenitors, they sense changes in shear stress resulting from surgery, and they interact with platelets and inflammatory\u00a0<span class=\"highlight\">cells<\/span>. LSECs also play a\u00a0<span class=\"highlight\">role<\/span>\u00a0in hepatocellular carcinoma development and progression, in ageing, and in\u00a0<span class=\"highlight\">liver<\/span>\u00a0lesions related to inflammation and infection. This review also presents a detailed analysis of the technical aspects relevant for LSEC analysis including the markers these\u00a0<span class=\"highlight\">cells<\/span>\u00a0express, the available cell lines and the transgenic mouse models. Finally, this review provides an overview of the strategies available for a specific targeting of LSECs.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liver sinusoidal endothelial cells: physiology and role in liver diseases - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liver sinusoidal endothelial cells: physiology and role in liver diseases - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/liver-sinusoidal-endothelial-cells-physiology-and-role-in-liver-diseases\\\/\",\"name\":\"Liver sinusoidal endothelial cells: physiology and role in liver diseases - 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