{"id":13371,"date":"2019-03-13T11:16:26","date_gmt":"2019-03-13T10:16:26","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&p=13371"},"modified":"2025-09-11T16:48:04","modified_gmt":"2025-09-11T14:48:04","slug":"hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury\/","title":{"rendered":"Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13371","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Hepatol.","date_de_publication":"20160115","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Tatsumi K"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Antoniak S"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Owens AP"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sparkenbaugh E"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Holle LA"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Wolberg AS"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Kopec AK"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pawlinski R"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Luyendyk JP"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mackman N"},{"texte_libre":false,"auteur-lien":13246,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lemoinne S"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Boulanger C"},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":false,"auteur-lien":13124,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26325534"}],"paragraphe":"

Abstract<\/h3>\r\n
\r\n

BACKGROUND & AIMS:<\/h4>\r\n

Patients with\u00a0chronic<\/span>\u00a0liver<\/span>\u00a0disease and cirrhosis have a dysregulated coagulation system and are prone to thrombosis. The basis for this\u00a0hypercoagulable<\/span>\u00a0state<\/span>\u00a0is not completely understood.\u00a0Tissue<\/span>\u00a0factor<\/span>\u00a0(TF) is the primary initiator of coagulation in vivo. Patients with cirrhosis have increased TF activity in white blood cells and circulating microparticles. The aim of our study was to determine the contribution of TF to the\u00a0hypercoagulable<\/span>\u00a0state<\/span>\u00a0in a\u00a0mouse<\/span>\u00a0model<\/span>\u00a0of\u00a0chronic<\/span>\u00a0liver<\/span>\u00a0injury<\/span>.<\/p>\r\n

METHODS:<\/h4>\r\n

We measured levels of TF activity in the\u00a0liver<\/span>, white blood cells and circulating microparticles, and a marker of activation of coagulation (thrombin-antithrombin complexes (TATc)) in the plasma of mice subjected to bile duct ligation for 12days. We used wild-type mice, mice with a global TF deficiency (low TF mice), and mice deficient for TF in either myeloid cells (TF(flox\/flox),LysMCre mice) or in hepatocytes (TF(flox\/flox),AlbCre).<\/p>\r\n

RESULTS:<\/h4>\r\n

Wild-type mice with\u00a0liver<\/span>\u00a0injury<\/span>\u00a0had increased levels of white blood cell, microparticle TF activity and TATc compared to sham mice. Low TF mice and mice lacking TF in hepatocytes had reduced levels of TF in the\u00a0liver<\/span>\u00a0and in microparticles and exhibited reduced activation of coagulation without a change in\u00a0liver<\/span>\u00a0fibrosis. In contrast, mice lacking TF in myeloid cells had reduced white blood cell TF but no change in microparticle TF activity or TATc.<\/p>\r\n

CONCLUSIONS:<\/h4>\r\n

Hepatocyte<\/span>\u00a0TF activates coagulation in a\u00a0mouse<\/span>\u00a0model<\/span>\u00a0of\u00a0chronic<\/span>\u00a0liver<\/span>\u00a0injury<\/span>. TF may contribute to the\u00a0hypercoagulable<\/span>\u00a0state<\/span>\u00a0associated with\u00a0chronic<\/span>\u00a0liver<\/span>\u00a0diseases in patients.<\/p>\r\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"\nHepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-tissue-factor-contributes-to-the-hypercoagulable-state-in-a-mouse-model-of-chronic-liver-injury\\\/\",\"name\":\"Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury. - 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