{"id":13366,"date":"2018-03-30T10:05:08","date_gmt":"2018-03-30T09:05:08","guid":{"rendered":"http:\/\/cyber.pixilie.fr\/?post_type=publications&p=13366"},"modified":"2025-09-11T16:48:05","modified_gmt":"2025-09-11T14:48:05","slug":"hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis\/","title":{"rendered":"Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis."},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-13366","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"[:fr]Hepatology[:]","date_de_publication":"20181001","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Payanc\u00e9 A[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Silva-Junior G[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Bissonnette J[:]"},{"texte_libre":false,"auteur-lien":13245,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Pasquet B[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Levi C[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Roux O[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Nekachtali O[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Baiges A[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr] Hern\u00e1ndez-Gea V[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Laou\u00e9nan C[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr] Lebrec D[:]"},{"texte_libre":false,"auteur-lien":13019,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":false,"auteur-lien":13124,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Boulanger CM[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Garcia-Pagan JC[:]"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"[:fr]Payanc\u00e9 A, Silva-Junior G, Bissonnette J, Tanguy M, Pasquet B, Levi C, Roux O, Nekachtali O, Baiges A, Hern\u00e1ndez-Gea V, Laou\u00e9nan C, Lebrec D, Albuquerque M, Paradis V, Moreau R, Valla D, Durand F, Boulanger CM, Garcia-Pagan JC, Rautou PE[:]","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29603327"}],"paragraphe":"[:fr]

Abstract<\/h3>\r\n
\r\n

Microvesicles (MVs) are extracellular vesicles released by cells following activation or apoptosis. Some MV subpopulations augment with\u00a0cirrhosis<\/span>\u00a0severity and contribute to portal hypertension. This study aimed at determining if plasma MV\u00a0levels<\/span>\u00a0can estimate the presence of hepatic venous pressure gradient (HVPG) \u226510 mm Hg and predict\u00a0mortality<\/span>\u00a0in\u00a0patients<\/span>\u00a0with advanced chronic liver disease. All\u00a0patients<\/span>\u00a0with severe fibrosis or\u00a0cirrhosis<\/span>\u00a0undergoing liver catheterization between 2013 and 2015 at two centers were prospectively included. We measured circulating\u00a0levels<\/span> of annexin V+, platelet, leukocyte, endothelial, and\u00a0hepatocyte<\/span>\u00a0MVs. The test cohort included 139\u00a0patients<\/span>.\u00a0Hepatocyte<\/span>\u00a0MV\u00a0levels<\/span>\u00a0were 4.0-fold and 2.2-fold higher in\u00a0patients<\/span>\u00a0with Child-Pugh C than in those with Child-Pugh A or B liver disease, respectively.\u00a0Levels<\/span>\u00a0of other MV subpopulations were not influenced by liver disease severity.\u00a0Hepatocyte<\/span>\u00a0MV\u00a0levels<\/span>\u00a0correlated with HVPG but could not identify\u00a0patients<\/span>\u00a0with HVPG \u226510 mm Hg.\u00a0Hepatocyte<\/span>\u00a0MV level >65 U\/L predicted 6-month\u00a0mortality<\/span>\u00a0independently of Child-Pugh score and of Model for End-Stage Liver Disease (MELD).\u00a0Patients<\/span>\u00a0with\u00a0hepatocyte<\/span>\u00a0MV\u00a0levels<\/span>\u00a0>65 U\/L and MELD >15 had a higher 6-month\u00a0mortality<\/span>\u00a0than other\u00a0patients<\/span>\u00a0(23% versus 3%; P = 0.001). These findings were confirmed in a validation cohort including 103\u00a0patients<\/span>.<\/p>\r\n

CONCLUSION:<\/h4>\r\n

Circulating MV\u00a0levels<\/span>\u00a0cannot identify\u00a0patients<\/span> with HVPG \u226510 mm Hg; by contrast, hepatocyte <\/span>MV levels <\/span>strongly improve <\/span>prediction<\/span> of 6-month mortality<\/span>\u00a0in\u00a0patients<\/span>\u00a0with advanced chronic liver disease; therapies associated with decreased\u00a0levels<\/span>\u00a0of circulating\u00a0hepatocyte<\/span>\u00a0MV might be attractive strategies in\u00a0patients<\/span>\u00a0with severe\u00a0cirrhosis<\/span>. (Hepatology 2018).<\/p>\r\n<\/div>[:]","paragraphe_en":"","documents":null},"yoast_head":"\nHepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis. - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis. - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:48:05+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-microvesicle-levels-improve-prediction-of-mortality-in-patients-with-cirrhosis\\\/\",\"name\":\"Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis. - 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