{"id":77936,"date":"2021-11-12T15:17:16","date_gmt":"2021-11-12T14:17:16","guid":{"rendered":"https:\/\/cri1149.fr\/actuetu\/a-gene-signature-as-a-surrogate-marker-of-microvascular-invasion-in-hepatocellular-carcinoma\/"},"modified":"2021-11-12T15:17:16","modified_gmt":"2021-11-12T14:17:16","slug":"a-gene-signature-as-a-surrogate-marker-of-microvascular-invasion-in-hepatocellular-carcinoma","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/news\/a-gene-signature-as-a-surrogate-marker-of-microvascular-invasion-in-hepatocellular-carcinoma\/","title":{"rendered":"A gene signature as a surrogate marker of microvascular invasion in hepatocellular carcinoma"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 18pt;\"><strong>Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\">Beaufr\u00e8re A, Caruso S, Calderaro J, Pot\u00e9 N, Bijot JC, Couchy G, Cauchy F, Vilgrain V, Zucman-Rossi J, Paradis V.<\/p>\n<p style=\"text-align: justify;\">J Hepatol. 2021 Oct 5:S0168-8278(21)02099-7. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34624411\/\">doi: 10.1016\/j.jhep.2021.09.034.<\/a><\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Short abstract:<\/strong><\/p>\n<p style=\"text-align: justify;\">Microvascular invasion (MVI), a major risk factor of tumor recurrence after surgery in hepatocellular carcinoma (HCC), is only detectable by microscopic examination of the surgical specimen. \u00a0In this study, we identified, by using NanoString technology, a 6-gene signature (ROS1, UGT2B7, FAS, ANGPTL7, GMNN, MKI67) strongly associated with MVI (training set of 109 FFPE surgical HCC samples: AUC 0.82, validation set of 69 FFPE HCC biopsies:\u00a0 AUC 0.74). Moreover, in multivariate analysis, the MVI signature was associated with overall survival in both sets (HR: 2.29, p=0.041). This MVI signature may be thus applied in clinical practice with routine tumor biopsy and integrated into the therapeutic strategy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies Beaufr\u00e8re A, Caruso S, Calderaro J, Pot\u00e9 N, Bijot JC, Couchy G, Cauchy F, Vilgrain [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[327],"tags":[],"class_list":["post-77936","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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