{"id":77912,"date":"2021-05-07T12:33:14","date_gmt":"2021-05-07T10:33:14","guid":{"rendered":"https:\/\/cri1149.fr\/actuetu\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\/"},"modified":"2021-05-07T12:33:14","modified_gmt":"2021-05-07T10:33:14","slug":"targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/news\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\/","title":{"rendered":"Targeting cell-intrinsic metabolism for antifibrotic therapy"},"content":{"rendered":"<p style=\"text-align: justify;\">Liver fibrosis and its end-stage, cirrhosis is a growing health burden worldwide. Liver fibrosis is the common wound healing response associated with chronic liver injury. In recent years, there have been major advances in our understanding of the mechanisms underlying fibrosis progression, and how coordinated interactions between parenchymal and non-parenchymal cells impact on the fibrogenic process. However, efficient therapy is still pending. This review by Lotersztajn\/Gilgenkrantz team approaches the issue of how targeting cell-intrinsic metabolism impact on fibrosis progression from the angle view of each cell type (hepatic stellate cell, Kupffer cell, hepatocyte or endothelial cell) in order to better define new antifibrotic therapeutic options.<\/p>\n<p style=\"text-align: center;\"><span style=\"text-decoration: underline;\"><em><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33631228\/\">Pubmed Link<\/a><\/strong><\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liver fibrosis and its end-stage, cirrhosis is a growing health burden worldwide. Liver fibrosis is the common wound healing response associated with chronic liver injury. In recent years, there have [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[327],"tags":[],"class_list":["post-77912","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeting cell-intrinsic metabolism for antifibrotic therapy - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/actuetu\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting cell-intrinsic metabolism for antifibrotic therapy - CRI\" \/>\n<meta property=\"og:description\" content=\"Liver fibrosis and its end-stage, cirrhosis is a growing health burden worldwide. Liver fibrosis is the common wound healing response associated with chronic liver injury. In recent years, there have [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/actuetu\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-07T10:33:14+00:00\" \/>\n<meta name=\"author\" content=\"Julien Tourneur-Marsille\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien Tourneur-Marsille\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\\\/?lang=en#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\\\/?lang=en\"},\"author\":{\"name\":\"Julien Tourneur-Marsille\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/person\\\/8d52142957854ee6b1081a095b93ffb6\"},\"headline\":\"Targeting cell-intrinsic metabolism for antifibrotic therapy\",\"datePublished\":\"2021-05-07T10:33:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\\\/?lang=en\"},\"wordCount\":114,\"publisher\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\"},\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\\\/?lang=en\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/targeting-cell-intrinsic-metabolism-for-antifibrotic-therapy\\\/?lang=en\",\"name\":\"Targeting cell-intrinsic metabolism for antifibrotic therapy - 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