{"id":77881,"date":"2020-07-23T13:32:18","date_gmt":"2020-07-23T12:32:18","guid":{"rendered":"https:\/\/cri1149.fr\/actualites\/short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition\/"},"modified":"2020-07-23T13:32:18","modified_gmt":"2020-07-23T12:32:18","slug":"short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/news-of-the-month\/short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition\/","title":{"rendered":"Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?"},"content":{"rendered":"<p style=\"text-align: center;\">Annu Rev Nutr. 2020 Jul 6.<\/p>\n<p style=\"text-align: center;\"><strong>Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?<\/strong><\/p>\n<p style=\"text-align: center;\">Johanne Le Beyec , Lore Billiauws , Andr\u00e9 Bado, Francisca Joly, Maude Le Gall<br \/>\nPMID: 32631145 DOI: 10.1146\/annurev-nutr-011720-122203<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">Short bowel syndrome (SBS) is a rare disease that results from extensive \u00a0resection of the intestine. When the remaining absorption surface of the intestine cannot absorb enough macronutrients, micronutrients, and water, SBS results in intestinal failure. Patients with SBS who suffer from intestinal failure require parenteral nutrition for survival, but long-term parenteral nutrition may also lead to complications such as catheter sepsis or thrombosis and metabolic liver diseases, renal failure and oxalic lithiasis.<\/p>\n<p style=\"text-align: justify;\">Spontaneous intestinal adaptation occurs weeks to months after resection,resulting in hyperplasia of the remnant gut, modification of gut hormone levels, dysbiosis (i.e;. modification of the intestinal microbiota), and hyperphagia. Oral nutrition and presence of the colon are two major positive drivers for this adaptation.<\/p>\n<p style=\"text-align: justify;\">This review aims to summarize the current knowledge of the mechanisms underlying spontaneous intestinal adaptation, particularly in response to modifications of luminal content, including nutrients. In the future, dietary manipulations could be used to treat SBS<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-15738\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article-300x193.png\" alt=\"\" width=\"560\" height=\"360\" srcset=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article-300x193.png 300w, https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article-768x495.png 768w, https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article-947x611.png 947w, https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article-624x402.png 624w, https:\/\/cri1149.fr\/wp-content\/uploads\/2020\/07\/figure-maude-article.png 1016w\" sizes=\"auto, (max-width: 560px) 100vw, 560px\" \/><\/p>\n<p><strong>Figure : Three anatomical subtypes of short bowel syndrome. <\/strong><\/p>\n<ol>\n<li>Small bowel resection with jejunostomy.<\/li>\n<li>Small bowel resection with removal of ileum, ileocecal valve, and part of the colon, resulting in jejunocolic anastomosis.<\/li>\n<li>Small bowel resection in which some ileum is preserved and the ileocecal valve and colon remain intact, resulting in jejunoileal anastomosis<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Annu Rev Nutr. 2020 Jul 6. Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition? Johanne Le Beyec , Lore Billiauws , Andr\u00e9 Bado, Francisca Joly, Maude Le Gall [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[328],"tags":[],"class_list":["post-77881","post","type-post","status-publish","format-standard","hentry","category-news-of-the-month"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition? - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/en\/news-of-the-month\/short-bowel-syndrome-a-paradigm-for-intestinal-adaptation-to-nutrition\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition? - CRI\" \/>\n<meta property=\"og:description\" content=\"Annu Rev Nutr. 2020 Jul 6. 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