{"id":77844,"date":"2018-10-15T15:46:16","date_gmt":"2018-10-15T14:46:16","guid":{"rendered":"https:\/\/cri1149.fr\/actualites\/bados-team-in-collaboration-with-pr-sokols-team-publishes-in-cell-metab\/"},"modified":"2018-10-15T15:46:16","modified_gmt":"2018-10-15T14:46:16","slug":"bados-team-in-collaboration-with-pr-sokols-team-publishes-in-cell-metab","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/news\/bados-team-in-collaboration-with-pr-sokols-team-publishes-in-cell-metab\/","title":{"rendered":"Bado&#8217;s team, in collaboration  with Pr Sokol&#8217;s team publishes, in Cell Metab."},"content":{"rendered":"<h2 class=\"section-title\" style=\"color: #505050;\">Summary<\/h2>\n<div id=\"abssec0010\" style=\"color: #505050;\">\n<p id=\"abspara0010\" style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt; color: #808080;\">The extent to which microbiota alterations define or influence the outcome of\u00a0<a style=\"color: #007398;\" title=\"Learn more about Inborn error of metabolism\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/inborn-error-of-metabolism\"><span style=\"color: #808080;\">metabolic diseases<\/span><\/a>\u00a0is still unclear, but the byproducts of microbiota metabolism are known to have an important role in mediating the host-microbiota interaction. Here, we identify that in both\u00a0<a style=\"color: #007398;\" title=\"Learn more about Pre-clinical development\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pre-clinical-development\"><span style=\"color: #808080;\">pre-clinical<\/span><\/a>\u00a0and clinical settings,\u00a0<a style=\"color: #007398;\" title=\"Learn more about Metabolic syndrome\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metabolic-syndrome\"><span style=\"color: #808080;\">metabolic syndrome<\/span><\/a>\u00a0is associated with the reduced capacity of the microbiota to metabolize\u00a0<a style=\"color: #007398;\" title=\"Learn more about Tryptophan\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/tryptophan\"><span style=\"color: #808080;\">tryptophan<\/span><\/a>\u00a0into derivatives that are able to activate the\u00a0<a style=\"color: #007398;\" title=\"Learn more about Aryl Hydrocarbon Receptor\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/aryl-hydrocarbon-receptor\"><span style=\"color: #808080;\">aryl hydrocarbon receptor<\/span><\/a>. This alteration is not merely an effect of the disease as supplementation with AhR\u00a0<a style=\"color: #007398;\" title=\"Learn more about Agonist\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/agonist\"><span style=\"color: #808080;\">agonist<\/span><\/a>\u00a0or a\u00a0<em>Lactobacillus<\/em>\u00a0strain, with a\u00a0high AhR ligand-production capacity, leads to improvement of both dietary- and genetic-induced metabolic impairments, particularly\u00a0<a style=\"color: #007398;\" title=\"Learn more about Glucose\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glucose\"><span style=\"color: #808080;\">glucose<\/span><\/a>\u00a0dysmetabolism and liver\u00a0<a style=\"color: #007398;\" title=\"Learn more about Steatosis\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/steatosis\"><span style=\"color: #808080;\">steatosis<\/span><\/a>, through improvement of intestinal barrier function and secretion of\u00a0the\u00a0<a style=\"color: #007398;\" title=\"Learn more about Incretin\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/incretin\"><span style=\"color: #808080;\">incretin<\/span><\/a>\u00a0hormone\u00a0<a style=\"color: #007398;\" title=\"Learn more about Glucagon-like peptide-1\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/glucagon-like-peptide-1\"><span style=\"color: #808080;\">GLP-1<\/span><\/a>. These results highlight the role of gut microbiota-derived metabolites as a biomarker and as a basis for novel preventative or therapeutic interventions for\u00a0<a style=\"color: #007398;\" title=\"Learn more about Metabolic disorders\" href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/metabolic-disorders\"><span style=\"color: #808080;\">metabolic disorders<\/span><\/a>.<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/www.cri1149.fr\/wp-content\/uploads\/2018\/10\/bado.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-11400 \" src=\"http:\/\/www.cri1149.fr\/wp-content\/uploads\/2018\/10\/bado.jpg\" alt=\"bado\" width=\"503\" height=\"503\" \/><\/a><\/p>\n<p style=\"text-align: left;\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413118304443?via%3Dihub<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019\u00e9quipe d\u2019Andr\u00e9 Bado en collaboration l\u2019Equipe du Pr  Harry Sokol a publi\u00e9 un article dans Cell Metab. 2018, 28: 1-13, November 6, 2018.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[327,328],"tags":[],"class_list":["post-77844","post","type-post","status-publish","format-standard","hentry","category-news","category-news-of-the-month"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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