{"id":77828,"date":"2018-06-08T20:07:20","date_gmt":"2018-06-08T19:07:20","guid":{"rendered":"https:\/\/cri1149.fr\/actuetu\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\/"},"modified":"2018-06-08T20:07:20","modified_gmt":"2018-06-08T19:07:20","slug":"sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/news\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\/","title":{"rendered":"Sophie Lotersztajn and Richard Moreau&#8217;s Team publishes in Nature Communications &#8211; June 2018"},"content":{"rendered":"<p style=\"text-align: justify;\">Liver fibrosis is the common response to chronic liver injury, and leads to cirrhosis and its complications. Persistent inflammation is a driving force of liver fibrosis progression. Mucosal-associated invariant T (MAIT) cells are non-conventional T cells that display altered functions during chronic inflammatory diseases. Here, we show that circulating MAIT cells are reduced in patients with alcoholic or non-alcoholic fatty liver disease-related cirrhosis while they accumulate in liver fibrotic septa. Using two models of chronic liver injury, we demonstrate that MAIT cell-enriched mice show increased liver fibrosis and accumulation of hepatic fibrogenic cells, whereas MAIT cell-deficient mice are resistant. Co-culture experiments indicate that MAIT cells enhance the proinflammatory properties of monocyte-derived macrophages, and promote mitogenic and proinflammatory functions of fibrogenic cells, via distinct mechanisms. Our results highlight the profibrogenic functions of MAIT cells and suggest that targeting MAIT cells may constitute an attractive antifibrogenic strategy during chronic liver injury.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Communications<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[327],"tags":[],"class_list":["post-77828","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sophie Lotersztajn and Richard Moreau&#039;s Team publishes in Nature Communications - June 2018 - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/actuetu\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\/?lang=en\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sophie Lotersztajn and Richard Moreau&#039;s Team publishes in Nature Communications - June 2018 - CRI\" \/>\n<meta property=\"og:description\" content=\"Nature Communications\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/actuetu\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\/?lang=en\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-08T19:07:20+00:00\" \/>\n<meta name=\"author\" content=\"Julien Tourneur-Marsille\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Julien Tourneur-Marsille\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\\\/?lang=en#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/actuetu\\\/sophie-lotersztajn-and-richard-moreaus-team-publishes-in-nature-communications-june-2018\\\/?lang=en\"},\"author\":{\"name\":\"Julien Tourneur-Marsille\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/person\\\/8d52142957854ee6b1081a095b93ffb6\"},\"headline\":\"Sophie Lotersztajn and Richard Moreau&#8217;s Team publishes in Nature Communications &#8211; 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