{"id":17591,"date":"2021-02-17T13:56:42","date_gmt":"2021-02-17T12:56:42","guid":{"rendered":"https:\/\/cri1149.fr\/?p=17591"},"modified":"2025-12-03T18:02:54","modified_gmt":"2025-12-03T17:02:54","slug":"etude-covid-19-des-cellules-immunitaires-associees-aux-muqueuses-impliquees-dans-la-severite-de-linfection","status":"publish","type":"post","link":"https:\/\/cri1149.fr\/en\/actualites\/etude-covid-19-des-cellules-immunitaires-associees-aux-muqueuses-impliquees-dans-la-severite-de-linfection\/","title":{"rendered":"Etude \u2013 COVID-19 : des cellules immunitaires associ\u00e9es aux muqueuses impliqu\u00e9es dans la s\u00e9v\u00e9rit\u00e9 de l\u2019infection"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>L\u2019\u00e9quipe de l\u2019unit\u00e9 fonctionnelle dysfonctionnements immunitaires dirig\u00e9e par le Pr Renato Monteiro au sein de l\u2019h\u00f4pital Bichat\u2013Claude-Bernard AP-HP, d\u2019Universit\u00e9 de Paris, de l\u2019Inserm et du CNRS, et l\u2019\u00e9quipe immunologie du diab\u00e8te dirig\u00e9e par Dr Agn\u00e8s Lehuen, au sein de l\u2019Institut Cochin (Inserm\/CNRS\/Universit\u00e9 de Paris), ont men\u00e9 des travaux en collaboration avec des cliniciens et virologues des h\u00f4pitaux de l\u2019AP-HP Bichat-Claude-Bernard, Cochin et Lariboisi\u00e8re, du CHU et de l&#8217;Inserm U1100 de Tours. Ces recherches ont permis de d\u00e9montrer le r\u00f4le des cellules immunitaires MAIT (Mucosal Associated Invariant T cells) dans l\u2019infection par le virus SARS-CoV-2. Cette \u00e9tude met en lumi\u00e8re de nouveaux m\u00e9canismes pathog\u00e8nes liant les fonctions inflammatoires et tueuses des cellules MAIT avec la s\u00e9v\u00e9rit\u00e9 et la mortalit\u00e9 de la maladie. Ces r\u00e9sultats sont publi\u00e9s dans la revue <\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41590-021-00870-z\"><strong><em>Nature Immunology<\/em><\/strong><\/a><strong><em>, <\/em><\/strong><strong>le 2 f\u00e9vrier 2021<em>.<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Le SARS-CoV-2 est responsable de la pand\u00e9mie COVID-19 qui a d\u00e9but\u00e9 en d\u00e9cembre 2019. L\u2019infection par ce virus peut induire dans certains cas un syndrome de d\u00e9tresse respiratoire aigu\u00eb d\u00fb \u00e0 une r\u00e9ponse inflammatoire incontr\u00f4l\u00e9e. Les cellules MAIT, pr\u00e9sentes dans les poumons, jouent un r\u00f4le important dans la d\u00e9tection et la lutte contre les infections bact\u00e9riennes et virales. Afin de d\u00e9terminer le ph\u00e9notype des cellules MAIT dans la COVID-19, l\u2019\u00e9tude a \u00e9t\u00e9 men\u00e9e sur plus de 150 patients hospitalis\u00e9s ou personnes non-infect\u00e9es.<\/p>\n<p style=\"text-align: justify;\">Que font les cellules immunitaires MAIT alors que le corps lutte contre le SARS-CoV-2 ? Leur fr\u00e9quence diminue drastiquement dans le sang des patients atteints de COVID-19 alors qu\u2019elle augmente dans le poumon. Chez ces patients, les cellules MAIT sont tr\u00e8s activ\u00e9es, et produisent de grandes quantit\u00e9s de cytokines pro-inflammatoires ainsi que des facteurs capables de tuer des cellules cibles. Plus les \u00ab\u00a0patients COVID-19\u00a0\u00bb sont dans un \u00e9tat grave, plus ces alt\u00e9rations des cellules MAIT sont importantes. D\u00e9terminer l\u2019\u00e9tendue du dysfonctionnement des cellules MAIT sanguines permet de pr\u00e9dire la survie des patients.<\/p>\n<p style=\"text-align: justify;\">Les auteurs de cette publication ont montr\u00e9 que dans le sang des \u00ab\u00a0patients COVID-19\u00a0\u00bb, plus la maladie est s\u00e9v\u00e8re, plus il y a de monocytes inflammatoires. Les monocytes des patients hospitalis\u00e9s en maladies infectieuses produisent plus d\u2019IFN\u03b1, une cytokine r\u00e9duisant la charge virale, alors que ceux des patients en r\u00e9animation produisent plus d\u2019IL-15 et d\u2019IL-18, des cytokines qui favorisent la r\u00e9action inflammatoire incontr\u00f4l\u00e9e et l\u2019activation des cellules MAIT.<\/p>\n<p style=\"text-align: justify;\">Par des exp\u00e9riences de cultures de cellules immunitaires, les scientifiques ont d\u00e9montr\u00e9 que l\u2019infection par le SARS-CoV-2 de macrophages, les principales cellules immunitaires du poumon, induit l\u2019activation et les fonctions tueuses des cellules MAIT, qui peuvent ainsi \u00e9liminer ces cellules infect\u00e9es mais \u00e9galement induire des l\u00e9sions tissulaires.<\/p>\n<p style=\"text-align: justify;\">L\u2019ensemble de cette \u00e9tude a mis en \u00e9vidence un r\u00f4le d\u00e9l\u00e9t\u00e8re des cellules MAIT dans les cas graves de COVID-19. Ces r\u00e9sultats permettent ainsi d\u2019utiliser ces cellules comme marqueurs de s\u00e9v\u00e9rit\u00e9 de l\u2019infection et de pronostic pr\u00e9coce pour les patients hospitalis\u00e9s atteints de cette maladie. Bloquer l\u2019action tueuse de ces cellules pourrait repr\u00e9senter une nouvelle approche th\u00e9rapeutique.<a href=\"https:\/\/cri1149.fr\/etude-covid-19-des-cellules-immunitaires-associees-aux-muqueuses-impliquees-dans-la-severite-de-linfection\/actuetu\/attachment\/publi-renato-covid-2\/\" rel=\"attachment wp-att-17596\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-17596\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2.jpg\" alt=\"\" width=\"1231\" height=\"757\" srcset=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2.jpg 1231w, https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2-300x184.jpg 300w, https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2-1024x630.jpg 1024w, https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2-768x472.jpg 768w, https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2-947x582.jpg 947w, https:\/\/cri1149.fr\/wp-content\/uploads\/2021\/02\/publi-renato-Covid-2-624x384.jpg 624w\" sizes=\"auto, (max-width: 1231px) 100vw, 1231px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><strong><em>L\u00e9gende de la figure<\/em><\/strong><em>: Chez les patients COVID-19, plus la pathologie est s\u00e9v\u00e8re, plus les cellules MAIT sont recrut\u00e9es dans les poumons, elles produisent des cytokines pro-inflammatoires et deviennent des cellules tueuses pouvant endommager les tissus pulmonaires. Ces modifications pathologiques des cellules MAIT sont associ\u00e9es \u00e0 la pr\u00e9sence accrue de monocytes\/macrophages qui produisent plus d\u2019IL-18 pro-inflammatoire et moins d\u2019IFN\u03b1 antiviral. <\/em><\/p>\n<p style=\"text-align: justify;\"><em>\u00a0<\/em><\/p>\n<p style=\"text-align: justify;\"><strong>R\u00e9f\u00e9rence\u00a0:<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity <\/strong>: H\u00e9lo\u00efse Flament<sup>1,2<\/sup>\u2022, Matthieu Rouland<sup>3<\/sup>,\u2022, Lucie Beaudoin<sup>3<\/sup>,\u2022, Amine Toubal<sup>3<\/sup>, \u2022, L\u00e9o Bertrand<sup>3<\/sup>, \u03ee, Samuel Lebourgeois<sup>4<\/sup>,\u03ee, Camille Rousseau<sup>3<\/sup>, Pauline Soulard<sup>3<\/sup>, Zouriatou Gouda<sup>3<\/sup>, Lucie Cagninacci<sup>3<\/sup>, Antoine C. Monteiro<sup>4<\/sup>, Margarita Hurtado-Nedelec<sup>1,2<\/sup>, Sandrine Luce<sup>3<\/sup>, Karine Bailly<sup>3<\/sup>, Muriel Andrieu<sup>3<\/sup>, Benjamin Saintpierre<sup>3<\/sup>, Franck Letourneur<sup>3<\/sup>, Youenn Jouan<sup>5,6<\/sup>, Mustapha Si-Tahar<sup>5<\/sup>, Thomas Baranek<sup>5<\/sup>, Christophe Paget<sup>5<\/sup>, Christian Boitard<sup>3,7<\/sup>, Ana\u00efs Vallet-Pichard<sup>3,8<\/sup>, Jean-Fran\u00e7ois Gautier<sup>9<\/sup>, Nadine Ajzenberg<sup>10<\/sup>, Benjamin Terrier<sup>11<\/sup>, Fr\u00e9d\u00e9ric P\u00e8ne<sup>3,12<\/sup>, Jade Ghosn<sup>13<\/sup>, Xavier Lescure<sup>13<\/sup>, Yazdan Yazdanpanah<sup>13<\/sup>, Benoit Visseaux<sup>4<\/sup>, Diane Descamps<sup>4<\/sup>, Jean-Fran\u00e7ois Timsit<sup>14<\/sup>, Renato C. Monteiro<sup>1,2<\/sup>, Agn\u00e8s Lehuen<sup>3<\/sup> (\u2022,\u03ee\u00a0 co-auteurs). <strong><em>Nature immunology.<\/em><\/strong> <strong><em>2021 Feb 2<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">DOI:\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41590-021-00870-z\">10.1038\/s41590-021-00870-z<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019\u00e9quipe de l\u2019unit\u00e9 fonctionnelle dysfonctionnements immunitaires dirig\u00e9e par le Pr Renato Monteiro au sein de l\u2019h\u00f4pital Bichat\u2013Claude-Bernard AP-HP, d\u2019Universit\u00e9 de Paris, de l\u2019Inserm et du CNRS, et l\u2019\u00e9quipe immunologie du [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[85],"tags":[],"class_list":["post-17591","post","type-post","status-publish","format-standard","hentry","category-actualites"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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