{"id":77600,"date":"2017-08-21T16:19:13","date_gmt":"2017-08-21T14:19:13","guid":{"rendered":"https:\/\/cri1149.fr\/center\/"},"modified":"2026-07-29T11:10:36","modified_gmt":"2026-07-29T09:10:36","slug":"center","status":"publish","type":"page","link":"https:\/\/cri1149.fr\/en\/center\/","title":{"rendered":"Center"},"content":{"rendered":"\n<p>The Centre de Recherche sur l&#8217;Inflammation (CRI) was born on January<sup>1<\/sup>, 2014 following the active collaboration of three research units. CRB3- U773, U843 and UMRS 699. <\/p>\n\n<p>Europe&#8217;s leading research center specializing in the study of inflammatory mechanisms.  <strong>This joint research unit (INSERM, CNRS, Universit\u00e9 Paris Cit\u00e9) brings together the expertise of 14 teams and two junior research groups specialising in basic and clinical research into inflammation of the liver, kidneys, pancreas, gut and immune system.<\/strong><\/p>\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"760\" height=\"595\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Le-centre-CRI-2026.png\" alt=\"\" class=\"wp-image-83169\" style=\"aspect-ratio:1.2773462883312188;width:512px;height:auto\" srcset=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Le-centre-CRI-2026.png 760w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Le-centre-CRI-2026-300x235.png 300w\" sizes=\"auto, (max-width: 760px) 100vw, 760px\" \/><\/figure>\n\n<p>Today, the CRI brings together more than <strong>330<\/strong> <strong>researchers, engineers and administrative staff<\/strong> spread across two sites (Bichat and Beaujon) and collaborates with the Bichat and Beaujon hospitals. It is headed by Val\u00e9rie Paradis and co-headed by Sophie Lotersztajn. <\/p>\n\n<p>Le CRI est un acteur majeur du laboratoire d\u2019excellence Infibrex coordonn\u00e9 par B. Crestani, du RHU inFire (co-coordonn\u00e9 par B. Crestani, G. Steg &amp; E. Daugas), du FHU MOSAIC, du RHU Liver-Track, QUID-NASH et Operandi de MOSAIC.<\/p>\n\n<p>The aim of these teams, which make up the CRI, is to establish a \u2018Centre of Excellence\u2019 that links basic research with translational and clinical research into inflammatory diseases, and to ensure the best possible care for patients.<\/p>\n\n<p><strong>Scientific policy<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Promote<\/strong> and facilitate active collaboration between scientists and clinicians in inflammation research<\/li>\n\n\n\n<li><strong>Promoting<\/strong> the emergence of new research projects and teams in the field of inflammatory mechanisms<\/li>\n\n\n\n<li><strong>Contributing<\/strong> to the training of young researchers<\/li>\n\n\n\n<li><strong>Establish<\/strong> stronger academic and industrial partnerships to promote the application of research results<\/li>\n\n\n\n<li><strong>Contribute<\/strong> to France&#8217;s international reputation through high-quality research<\/li>\n<\/ul>\n\n<p><strong>CRI&#8217;s scientific objectives<br\/><\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Fundamental understanding of the basis of inflammatory processes and the development of fibrosis<\/li>\n\n\n\n<li>Identify new pathophysiological mechanisms and biomarkers associated with inflammatory diseases, and develop new imaging tools.<\/li>\n\n\n\n<li>Create new preclinical animal models for proof-of-concept (POC) studies of inflammatory diseases<\/li>\n\n\n\n<li>Search for new therapeutic approaches.<\/li>\n<\/ul>\n\n<p><strong>Scientific Topics:<\/strong><\/p>\n\n<ol class=\"wp-block-list\">\n<li>Pathophysiology of inflammatory and fibrotic diseases<\/li>\n\n\n\n<li>Oncogenic inflammation &amp; tumour development<\/li>\n\n\n\n<li>Signalling and dynamics of immune cells<\/li>\n<\/ol>\n\n<p><strong>3 cross-cutting research areas:<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Identify common features of inflammatory mechanisms in immune, endothelial and fibroblast cells (lung\/kidney\/digestive tract)<\/li>\n\n\n\n<li>Decipher the sequence of pro-oncogenic events in the context of inflammation Characterize tumor heterogeneity via the tumor microenvironment<\/li>\n\n\n\n<li>Describe the molecular mechanisms of the inflammatory response, in particular oxidative stress and intracellular traffic<\/li>\n<\/ul>\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"452\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-1024x452.png\" alt=\"\" class=\"wp-image-83166\" srcset=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-1024x452.png 1024w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-300x132.png 300w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-768x339.png 768w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-1536x678.png 1536w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026-1320x583.png 1320w, https:\/\/cri1149.fr\/wp-content\/uploads\/2026\/07\/Presentation-CRI-2026.png 1975w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Centre de Recherche sur l&#8217;Inflammation (CRI) was born on January1, 2014 following the active collaboration of three research units. CRB3- U773, U843 and UMRS 699. Europe&#8217;s leading research center specializing in the study of inflammatory mechanisms. This joint research unit (INSERM, CNRS, Universit\u00e9 Paris Cit\u00e9) brings together the expertise of 14 teams and two [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-77600","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Center - CRI<\/title>\n<meta name=\"description\" content=\"The CRI brings together researchers and clinicians to understand inflammatory mechanisms and develop new therapeutic approaches.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/en\/center\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Center - 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