The team of S Loterstajn and H Gilgenkrantz, in collaboration with V Paradis whithin the Centre de Recherche sur l’Inflammation, and the teams of O Lantz (I Curie) and M Goodhardt (Institut St Louis) recently showed that MAIT cell inhibition not only stops liver fibrosis progression but also promotes fibrosis regression. In analyzing the mechanisms involved, the authors showed that blocking MAIT cell activation inhibits the dialog with profibrogenic macrophages and promotes the emergence of resolutive macrophages. These results open new therapeutic perspectives for liver cirrhosis.

This study is published in Nature Communications : 2023 Apr 1;14(1):1830. doi: 10.1038/s41467-023-37453-5. PMID: 37005415