ExtRacellular vEsicle Signature fOr LiVer disEases


It is estimated that “fatty liver disease”, which can escalate to cirrhosis and its complications, affects 25% of the world’s population. Improving the identification of patients at risk of developing complications is an unmet medical need and requires the identification of new readily available biomarkers.

Extracellular vesicles, vectors of information between cells and organs and carriers of protein markers reflecting the state of their original cells, have emerged in recent years as a source of attractive biomarkers in liver disease. The Rautou team has identified a new biomarker carried by extracellular vesicles that improves the prediction of the risk of death for patients with severe cirrhosis, but the transposition of this scientific discovery to the medical world comes up against Currently to technological limitations which make it difficult to measure vesicular proteins without the equipment of a research laboratory.

To overcome this technological difficulty, the Resolve project proposes the development of an innovative technology for the simultaneous detection of several vesicular proteins in plasma, designed to be used with the equipment available in all medical analysis laboratories.