Leader
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Ogier-Denis Eric
- 01 57 27 73 07
- eric.ogier-denis@inserm.fr
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Hugot Jean-Pierre
- 01 57 27 73 07
- jean-pierre.hugot@rdb.aphp.fr
Intestinal inflammation
The team “intestinal inflammation” works exclusively on inflammatory bowel disease (IBD): Crohn’s Disease (CD) and ulcerative colitis (UC). The research is deliberately multidisciplinary with a multi-scale approach from the molecular level to patients. This is a translational research strongly associated with the gastroenterology units of Beaujon and Robert Debré hospitals. Projects aim to identify the genetic and environmental risk factors involved in these diseases and to define their interactions. The team developed original animal models to better understand the pathophysiology of IBD in particular the importance of abnormalities of endoplasmic reticulum (ER) stress and epigenetic factors (microRNAs, methylation, and acetylation) in UC and the innate immune response and function of the complex molecular “Nodosome” around Nod2 in CD. Finally, the team aim to develop new preventive and curative therapeutic approaches for IBD.
Publication date : 06 October 2020 More
Autors : Viennois Emilie Alexis Bretin Philip E. Dube Alexander C. Maue Charle` ne J.G. Dauriat Nicolas Barnich Andrew T. Gewirtz Benoit Chassaing
Publication date : 19 June 2020 More
Autors : Al Nabhani Z Berrebi D Martinez-Vinson C Montcuquet N Madre C Roy Maryline Ogier-Denis Eric Dussaillant M Cerf-Bensussan N Zouali H Daniel F Barreau F Hugot Jean-Pierre
Publication date : 10 April 2020 More
Autors : Collard Maxime Guedj Nathalie Tourneur-Marsille Julien ALBUQUERQUE Miguel Maggiori Leon Hammel Pascal Treton Xavier Panis Yves Ogier-Denis Eric
Publication date : 01 October 2019 More
Autors : Dumay Anne Gergaud Olivier Roy Maryline Hugot Jean-Pierre
Publication date : 17 July 2019 More
Autors : Romagnoni Alberto Jégou S Van Steen K Wainrib G Hugot Jean-Pierre International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Publication date : 30 April 2019 More
Autors : Maurel M Obacz J Avril T Ding YP Papadodima O Treton Xavier Daniel F Pilalis E Hörberg J Hou W Beauchamp MC Tourneur-Marsille Julien Cazals-Hatem Dominique Sommerova L Samali A Tavernier J Hrstka R Dupont A Fessart D Delom F Fernandez-Zapico ME Jansen G Eriksson LA Thomas DY Jerome-Majewska L Hupp T Chatziioannou A Chevet E Ogier-Denis Eric
Publication date : 08 May 2012 More
Autors : Jung C Meinzer Ulrich Montcuquet N Thachil E Château D Thiébaut R Roy Maryline Alnabhani Z Berrebi D Dussaillant M Pedruzzi E Thenet S Cerf-Bensussan N Hugot Jean-Pierre Barreau F
Publication date : 01 May 2012 More
Autors : Thachil E Hugot Jean-Pierre Arbeille B Paris R Grodet A Peuchmaur M Codogno P Barreau F Ogier-Denis Eric Berrebi D Viala Jérome
Publication date : 05 May 2011 More
Autors : Treton Xavier Pédruzzi E Cazals-Hatem Dominique Grodet A Panis Yves Groyer A Moreau Richard Bouhnik Yoram Daniel F Ogier-Denis Eric
Publication date : 13 December 2003 More
Autors : Hugot Jean-Pierre Alberti C Berrebi D Bingen E Cézard JP
Publication date : 31 May 2001 More
Autors : Hugot Jean-Pierre Chamaillard M Zouali H Lesage S Cézard JP Belaiche J Almer S Tysk C O'Morain CA Gassull M Binder V Finkel Y Cortot A Modigliani R Laurent-Puig P Gower-Rousseau C Macry J Colombel JF Sahbatou M Thomas G