Leader
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Lotersztajn Sophie
- 01 57 27 74 29
- sophie.lotersztajn@inserm.fr
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Gilgenkrantz Hélène
- 01 57 27 75 30
- helene.gilgenkrantz@inserm.fr
Our team studies the mechanisms underlying chronic liver disease progression to cirrhosis and its complications, with an emphasis on the identification of prognosis markers and therapeutic targets for fatty liver diseases.Our research program focuses on the identification of immunometabolic targets and biomarkers of liver and systemic inflammation.
Non-alcoholic and alcoholic fatty liver diseases (NAFLD, ALD) are leading causes of liver diseases worldwide. They share common pathogenic features including steatosis and steatohepatitis (alcoholic-ASH and non-alcoholic-NASH) that lead to fibrosis and cirrhosis. Persistent inflammation is a driving force of liver fibrosis progression during NAFLD and ALD. Among patients with cirrhosis, excessive inflammation results in the development of multiorgan failure (defining acute-on-chronic liver failure, ACLF), which often leads to death. The lack of treatment highlights the urgent need for new prognosis markers and specific therapeutic targets that could limit liver injury, fibrosis, progression of cirrhosis to ACLF, and favour liver regeneration.
Ongoing studies include:
Networks : In addition to RHU QUID-NASH, our group is a founding team of the European Consortium for the Study of Chronic Liver Failure (EF-CLIF) and the French-Indian network (LIA) and Labex Inflamex.
Funding: Inserm, Université Paris-Diderot, Laboratory of Excellence Inflamex, National research agency (ANR), Fondation pour la Recherche médicale (FRM), french associations for the study of the liver and for digestive diseases (AFEF, SNFGE), RHU QUID-NASH Inserm-Transfert, Assistance Publique Hopitaux de Paris (PHRC),
Publication date : 01 June 2021 More
Autors : Gilgenkrantz Hélène Ariane Mallat Moreau Richard Lotersztajn Sophie
Publication date : 05 February 2021 More
Autors : Weiss Emmanuel Pierre de la Grange Mylène Defaye Juan José Lozano Ferrán Aguilar Pushpa Hegde Ariane Jolly Moga Lucile Sukriti Sukriti Banwari Agarwal Haqeeqat Gurm Tanguy Marion Poisson Johanne Joan Clària Paer-Selim Abback Perianin Axel Gautam Mehta Rajiv Jalan Francoz Claire Rautou Pierre-Emmanuel Lotersztajn Sophie Vicente Arroyo Durand François Moreau Richard
Publication date : 01 July 2020 More
Autors : Ariane Mallat Lotersztajn Sophie
Publication date : 15 April 2020 More
Autors : Wan Jinghong Weiss Emmanuel Ben Mkaddem Sanae Mabire Morgane Pierre-Marie Choinier Olivia Picq Tristan Thibault-Sogorb Pushpa Hegde Dorsa Pishvaie Bens Marcelle Linda Broer Gilgenkrantz Hélène Moreau Richard Saveanu Loredana Patrice Codogno Monteiro Renato Lotersztajn Sophie
Publication date : 01 October 2019 More
Autors : Toubal A Nel I Lotersztajn Sophie Lehuen A
Publication date : 01 May 2019 More
Autors : Allaire Manon Rautou Pierre-Emmanuel Codogno P Lotersztajn Sophie
Publication date : 01 April 2019 More
Autors : Durand François Levitsky J Cauchy F Gilgenkrantz Hélène Soubrane Olivier Francoz Claire
Publication date : 01 December 2018 More
Autors : Moreau Richard Elkrief Laure Bureau C Perarnau JM Thévenot T Saliba F Louvet A Nahon P Lannes A Anty R Hillaire S Pasquet B Ozenne V Rudler M Ollivier-Hourmand I Robic MA Di Martino V Ripault MP Pauwels A Grangé JD Carbonell N Bronowicki JP Payancé A Rautou Pierre-Emmanuel Valla Dominique Gault N Lebrec D NORFLOCIR Trial Investigators
Publication date : 09 October 2018 More
Autors : Habib Aida Chokr D Wan Jinghong Hegde P Mabire Morgane Siebert M Ribeiro-Parenti Lara Le Gall Maude Letteron Philippe Pilard N Mansouri Abdellah Brouillet A Tardelli M Weiss Emmanuel Le Faouder P Guillou H Cravatt BF Moreau Richard Trauner M Lotersztajn Sophie
Publication date : 01 June 2018 More
Autors : Hegde P Weiss Emmanuel Paradis Valérie Wan Jinghong Mabire Morgane Sukriti S Rautou Pierre-Emmanuel ALBUQUERQUE Miguel Picq O Gupta AC Ferrere G Gilgenkrantz Hélène Kiaf B Toubal A Beaudoin L Letteron Philippe Moreau Richard Lehuen A Lotersztajn Sophie
Publication date : 01 June 2018 More
Autors : Abitbol S Dahmani R Coulouarn C Ragazzon B Mlecnik B Senni N Savall M Bossard P Sohier P Drouet V Tournier E Dumont F Sanson R Calderaro J Zucman-Rossi J Vasseur-Cognet M Just PA Terris B Perret C Gilgenkrantz Hélène
Publication date : 14 August 2015 More
Autors : Lodder J Denaës T Chobert MN Wan Jinghong El Benna Jamel Pawlotsky JM Lotersztajn Sophie Teixeira-Clerc F