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Photo d'équipe Hugot

Host-Environment interface in chronic inflammatory disorders

Team Hugot

Department Hepato-Gastroenterology Department







Increasing evidence has implicated a disruption of host immune-microbial interaction and luminal microbial dysbiosis – term referring to an alteration of the intestinal microbiota – in the pathogenesis of IBD and other chronic inflammatory disorders. Our research focuses on considering the intestinal interface between the outer and the inner parts of the intestine, seeking to explain how this interface operates to mediate host-microbiota interactions impacting the physiopathology of chronic inflammatory diseases. Notwithstanding our interest for IBD, we also explore other chronic inflammatory diseases related to an altered host-microbiota dialogue, such as arthritis. Both conditions are used and seen as diseases model of intestinal and extra-intestinal inflammation. Our central objective aims to understanding how the gut interface can be determining in the initiation and development of dysbiosis-associated diseases appears crucial.

 Dysbiosis, early in life, has now been appreciated for its determining impact on intestinal health later in life. Several evidences made in both humans and mice indicate that individuals having a reduced contact with lives microbes, develop a pathological imprinting to IBD and to other chronic disorders such as rheumatoid arthritis later in life. In contrast, higher bacterial diversity in early life prevents illness development in adulthood. Therefore, our project focuses on both early events and those at the time of the disease.

Our fundamental question, fueled by clinical observations, is addressed according to three axes:

1) Explore how the outside world (environment, microbiota, diet) does impact the interface (OUTER). In an ongoing prospective exposed/non-exposed study, « MIKINAUTEs », we seek to understand how exogenous factors (food and exposome) can influence relapse and/or remission in IBD.

2) Understanding the interface itself (INTERFACE) with a special focus on intestinal miRNA and their role in host-microbiota interaction and more generally intestinal homeostasis.

3) Examine how the deregulation of the interface does impact distant organs potentially leading to extra-intestinal pathologies (INNER) such as arthritis. This axe seeks to determine how alterations of the intestinal barrier function and bacterial translocation can promote IBD, and similarly arthritis, and autoimmunity in genetically predisposed hosts.


Landmark publications

  • Publication date : 01 November 2022 More

    The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer
    Cell Mol Gastroenterol Hepatol.

    Autors : Collard Maxime Tourneur-Marsille Julien Mathieu Uzzan ALBUQUERQUE Miguel Roy Maryline Dumay Anne Jean-Noël Freund Hugot Jean-Pierre Guedj Nathalie Treton Xavier Panis Yves Ogier-Denis Eric

  • Publication date : 06 October 2020 More

    Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation
    Cell Reports

    Autors : Viennois Emilie Alexis Bretin Philip E. Dube Alexander C. Maue Charle` ne J.G. Dauriat Nicolas Barnich Andrew T. Gewirtz Benoit Chassaing

  • Publication date : 19 June 2020 More

    Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine
    J Crohns Colitis

    Autors : Al Nabhani Z Berrebi D Martinez-Vinson C Montcuquet N Madre C Roy Maryline Ogier-Denis Eric Dussaillant M Cerf-Bensussan N Zouali H Daniel F Barreau F Hugot Jean-Pierre

  • Publication date : 10 April 2020 More

    Immune-checkpoint inhibitor anti-PD1 aggravates colitis-associated colorectal cancer without enhancing intestinal inflammation
    Integrative Cancer Science and Therapeutics

    Autors : Collard Maxime Guedj Nathalie Tourneur-Marsille Julien ALBUQUERQUE Miguel Maggiori Leon Hammel Pascal Treton Xavier Panis Yves Ogier-Denis Eric

  • Publication date : 01 October 2019 More

    Is Crohn’s Disease the Price to Pay Today for Having Survived the Black Death?
    Journal of Crohn's and Colitis, Volume 13, Issue 10, October 2019, Pages 1318–1322

    Autors : Dumay Anne Gergaud Olivier Roy Maryline Hugot Jean-Pierre

  • Publication date : 17 July 2019 More

    Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
    Sci Rep. 2019 Jul 17;9(1):10351

    Autors : Romagnoni Alberto Jégou S Van Steen K Wainrib G Hugot Jean-Pierre International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)

  • Publication date : 30 April 2019 More

    Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
    EMBO Mol Med

    Autors : Maurel M Obacz J Avril T Ding YP Papadodima O Treton Xavier Daniel F Pilalis E Hörberg J Hou W Beauchamp MC Tourneur-Marsille Julien Cazals-Hatem Dominique Sommerova L Samali A Tavernier J Hrstka R Dupont A Fessart D Delom F Fernandez-Zapico ME Jansen G Eriksson LA Thomas DY Jerome-Majewska L Hupp T Chatziioannou A Chevet E Ogier-Denis Eric

  • Publication date : 08 May 2012 More

    Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
    J Clin Invest. 2012; 122: 2239-51

    Autors : Jung C Meinzer Ulrich Montcuquet N Thachil E Château D Thiébaut R Roy Maryline Alnabhani Z Berrebi D Dussaillant M Pedruzzi E Thenet S Cerf-Bensussan N Hugot Jean-Pierre Barreau F

  • Publication date : 01 May 2012 More

    Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn’s Disease Short title: Crinophagy in Crohn’s disease

    Autors : Thachil E Hugot Jean-Pierre Arbeille B Paris R Grodet A Peuchmaur M Codogno P Barreau F Ogier-Denis Eric Berrebi D Viala Jérome

  • Publication date : 05 May 2011 More

    Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
    Gastroenterology.2011 Sep;141(3):1024-35

    Autors : Treton Xavier Pédruzzi E Cazals-Hatem Dominique Grodet A Panis Yves Groyer A Moreau Richard Bouhnik Yoram Daniel F Ogier-Denis Eric

  • Publication date : 13 December 2003 More

    Crohn Disease : the cold chain hypothesis

    Autors : Hugot Jean-Pierre Alberti C Berrebi D Bingen E Cézard JP

  • Publication date : 31 May 2001 More

    Association of Nod-2 leucine-rich repeat variants with susceptibility to Crohn’s disease
    Nature 2001; 411 : 599-603

    Autors : Hugot Jean-Pierre Chamaillard M Zouali H Lesage S Cézard JP Belaiche J Almer S Tysk C O'Morain CA Gassull M Binder V Finkel Y Cortot A Modigliani R Laurent-Puig P Gower-Rousseau C Macry J Colombel JF Sahbatou M Thomas G


Site de référence pour les Appels à Projets

Les dernières publications marquantes

  • Publication date : 17 January 2023 More

    ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes

    Autors : Asma Tlili Pintard Coralie Hurtado-Nedelec Maria Margarita Liu Dan Viviana Marzaioli Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel

  • Publication date : 30 November 2022 More

    Comparative Analysis of a Locally Resampling MR Elastography Reconstruction Algorithm in Liver Fibrosis

    Autors : Page Gwenael JULEA Felicia Paradis Valérie Vilgrain Valérie Valla Dominique Van Beers Bernard Garteiser Philippe

  • Publication date : 03 November 2022 More

    JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
    Nature Communications.

    Autors : Rida Al-Rifai Marie Vandestienne Jean-Rémi Lavillegrand Tristan Mirault Julie Cornebise Poisson Johanne Ludivine Laurans Bruno Esposito Chloé James Olivier Mansier Pierre Hirsch Fabrizia Favale Rayan Braik Camille Knosp Jose Vilar Giuseppe Rizzo Alma Zernecke Antoine-Emmanuel Saliba Alain Tedgui Maxime Lacroix Lionel Arrive Ziad Mallat Soraya Taleb Marc Diedisheim Clément Cochain Rautou Pierre-Emmanuel Hafid Ait-Oufella