Leader
-
Hugot Jean-Pierre
- 01 57 27 73 07
- jean-pierre.hugot@rdb.aphp.fr
Host-Environment interface in chronic inflammatory disorders
Team Hugot
Department Hepato-Gastroenterology Department
Line-up
Team Leader
Permanent scientific
PhD student
Post-doctoral fellow
Presentation
Increasing evidence has implicated a disruption of host immune-microbial interaction and luminal microbial dysbiosis – term referring to an alteration of the intestinal microbiota – in the pathogenesis of IBD and other chronic inflammatory disorders. Our research focuses on considering the intestinal interface between the outer and the inner parts of the intestine, seeking to explain how this interface operates to mediate host-microbiota interactions impacting the physiopathology of chronic inflammatory diseases. Notwithstanding our interest for IBD, we also explore other chronic inflammatory diseases related to an altered host-microbiota dialogue, such as arthritis. Both conditions are used and seen as diseases model of intestinal and extra-intestinal inflammation. Our central objective aims to understanding how the gut interface can be determining in the initiation and development of dysbiosis-associated diseases appears crucial.
Dysbiosis, early in life, has now been appreciated for its determining impact on intestinal health later in life. Several evidences made in both humans and mice indicate that individuals having a reduced contact with lives microbes, develop a pathological imprinting to IBD and to other chronic disorders such as rheumatoid arthritis later in life. In contrast, higher bacterial diversity in early life prevents illness development in adulthood. Therefore, our project focuses on both early events and those at the time of the disease.
Our fundamental question, fueled by clinical observations, is addressed according to three axes:
1) Explore how the outside world (environment, microbiota, diet) does impact the interface (OUTER). In an ongoing prospective exposed/non-exposed study, « MIKINAUTEs », we seek to understand how exogenous factors (food and exposome) can influence relapse and/or remission in IBD.
2) Understanding the interface itself (INTERFACE) with a special focus on intestinal miRNA and their role in host-microbiota interaction and more generally intestinal homeostasis.
3) Examine how the deregulation of the interface does impact distant organs potentially leading to extra-intestinal pathologies (INNER) such as arthritis. This axe seeks to determine how alterations of the intestinal barrier function and bacterial translocation can promote IBD, and similarly arthritis, and autoimmunity in genetically predisposed hosts.
Landmark publications
-
Publication date : 01 November 2022 More
The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer
Cell Mol Gastroenterol Hepatol.
Autors : Collard Maxime Tourneur-Marsille Julien Mathieu Uzzan ALBUQUERQUE Miguel Roy Maryline Dumay Anne Jean-Noël Freund Hugot Jean-Pierre Guedj Nathalie Treton Xavier Panis Yves Ogier-Denis Eric
-
Publication date : 06 October 2020 More
Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation
Cell Reports
Autors : Viennois Emilie Alexis Bretin Philip E. Dube Alexander C. Maue Charle` ne J.G. Dauriat Nicolas Barnich Andrew T. Gewirtz Benoit Chassaing
-
Publication date : 19 June 2020 More
Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine
J Crohns Colitis
Autors : Al Nabhani Z Berrebi D Martinez-Vinson C Montcuquet N Madre C Roy Maryline Ogier-Denis Eric Dussaillant M Cerf-Bensussan N Zouali H Daniel F Barreau F Hugot Jean-Pierre
-
Publication date : 10 April 2020 More
Immune-checkpoint inhibitor anti-PD1 aggravates colitis-associated colorectal cancer without enhancing intestinal inflammation
Integrative Cancer Science and Therapeutics
Autors : Collard Maxime Guedj Nathalie Tourneur-Marsille Julien ALBUQUERQUE Miguel Maggiori Leon Hammel Pascal Treton Xavier Panis Yves Ogier-Denis Eric
-
Publication date : 01 October 2019 More
Is Crohn’s Disease the Price to Pay Today for Having Survived the Black Death?
Journal of Crohn's and Colitis, Volume 13, Issue 10, October 2019, Pages 1318–1322
Autors : Dumay Anne Gergaud Olivier Roy Maryline Hugot Jean-Pierre
-
Publication date : 17 July 2019 More
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
Sci Rep. 2019 Jul 17;9(1):10351
Autors : Romagnoni Alberto Jégou S Van Steen K Wainrib G Hugot Jean-Pierre International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
-
Publication date : 30 April 2019 More
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
EMBO Mol Med
Autors : Maurel M Obacz J Avril T Ding YP Papadodima O Treton Xavier Daniel F Pilalis E Hörberg J Hou W Beauchamp MC Tourneur-Marsille Julien Cazals-Hatem Dominique Sommerova L Samali A Tavernier J Hrstka R Dupont A Fessart D Delom F Fernandez-Zapico ME Jansen G Eriksson LA Thomas DY Jerome-Majewska L Hupp T Chatziioannou A Chevet E Ogier-Denis Eric
-
Publication date : 08 May 2012 More
Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
J Clin Invest. 2012; 122: 2239-51
Autors : Jung C Meinzer Ulrich Montcuquet N Thachil E Château D Thiébaut R Roy Maryline Alnabhani Z Berrebi D Dussaillant M Pedruzzi E Thenet S Cerf-Bensussan N Hugot Jean-Pierre Barreau F
-
Publication date : 01 May 2012 More
Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn’s Disease Short title: Crinophagy in Crohn’s disease
Gastroenterology.
Autors : Thachil E Hugot Jean-Pierre Arbeille B Paris R Grodet A Peuchmaur M Codogno P Barreau F Ogier-Denis Eric Berrebi D Viala Jérome
-
Publication date : 05 May 2011 More
Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
Gastroenterology.2011 Sep;141(3):1024-35
Autors : Treton Xavier Pédruzzi E Cazals-Hatem Dominique Grodet A Panis Yves Groyer A Moreau Richard Bouhnik Yoram Daniel F Ogier-Denis Eric
-
Publication date : 13 December 2003 More
Crohn Disease : the cold chain hypothesis
Lancet
Autors : Hugot Jean-Pierre Alberti C Berrebi D Bingen E Cézard JP
-
Publication date : 31 May 2001 More
Association of Nod-2 leucine-rich repeat variants with susceptibility to Crohn’s disease
Nature 2001; 411 : 599-603
Autors : Hugot Jean-Pierre Chamaillard M Zouali H Lesage S Cézard JP Belaiche J Almer S Tysk C O'Morain CA Gassull M Binder V Finkel Y Cortot A Modigliani R Laurent-Puig P Gower-Rousseau C Macry J Colombel JF Sahbatou M Thomas G