Leader(s)
-
Hugot Jean-Pierre
- 01 57 27 73 07
- jean-pierre.hugot@rdb.aphp.fr
Increasing evidence has implicated a disruption of host immune-microbial interaction and luminal microbial dysbiosis – term referring to an alteration of the intestinal microbiota – in the pathogenesis of IBD and other chronic inflammatory disorders. Our research focuses on considering the intestinal interface between the outer and the inner parts of the intestine, seeking to explain how this interface operates to mediate host-microbiota interactions impacting the physiopathology of chronic inflammatory diseases. Notwithstanding our interest for IBD, we also explore other chronic inflammatory diseases related to an altered host-microbiota dialogue, such as arthritis. Both conditions are used and seen as diseases model of intestinal and extra-intestinal inflammation. Our central objective aims to understanding how the gut interface can be determining in the initiation and development of dysbiosis-associated diseases appears crucial.
Dysbiosis, early in life, has now been appreciated for its determining impact on intestinal health later in life. Several evidences made in both humans and mice indicate that individuals having a reduced contact with lives microbes, develop a pathological imprinting to IBD and to other chronic disorders such as rheumatoid arthritis later in life. In contrast, higher bacterial diversity in early life prevents illness development in adulthood. Therefore, our project focuses on both early events and those at the time of the disease.
Our fundamental question, fueled by clinical observations, is addressed according to three axes:
1) Explore how the outside world (environment, microbiota, diet) does impact the interface (OUTER). In an ongoing prospective exposed/non-exposed study, « MIKINAUTEs », we seek to understand how exogenous factors (food and exposome) can influence relapse and/or remission in IBD.
2) Understanding the interface itself (INTERFACE) with a special focus on intestinal miRNA and their role in host-microbiota interaction and more generally intestinal homeostasis.
3) Examine how the deregulation of the interface does impact distant organs potentially leading to extra-intestinal pathologies (INNER) such as arthritis. This axe seeks to determine how alterations of the intestinal barrier function and bacterial translocation can promote IBD, and similarly arthritis, and autoimmunity in genetically predisposed hosts.
Publication date : 06 September 2023 More
Authors : Laury Sellem Bernard Srour Guillaume Javaux Eloi Chazelas Benoit Chassaing Viennois Emilie Charlotte Debras Clara Salamé Nathalie Druesne-Pecollo Younes Esseddik Fabien Szabo de Edelenyi Cédric Agaësse Alexandre De Sa Rebecca Lutchia Erwan Louveau Inge Huybrechts Fabrice Pierre Xavier Coumoul Léopold K Fezeu Chantal Julia Emmanuelle Kesse-Guyot Benjamin Allès Pilar Galan Serge Hercberg Mélanie Deschasaux-Tanguy Mathilde Touvier
Publication date : 21 August 2023 More
Authors : Céline Lafay Zein Assad Naïm Ouldali Emmanuel Bui Quoc Ana Clement Capucine Durand Selim Fares Albert Faye Laurye-Anne Eveillard Florentia Kaguelidou Cherif Titah Zaba Valtuille Caroline Vinit Meinzer Ulrich Cécile Dumaine
Publication date : 06 July 2023 More
Authors : Zaba Valtuille Alain Lefevre-Utile Naim Ouldali Constance Beyler Priscilla Boizeau Cécile Dumaine Arthur Felix Zein Assad Albert Faye Isabelle Melki Florentia Kaguelidou Meinzer Ulrich
Publication date : 20 June 2023 More
Authors : Casado-Bedmar Maite Roy Maryline Viennois Emilie
Publication date : 01 January 2023 More
Authors : Anthony Buisson Harry Sokol Nassim Hammoudi Stéphane Nancey Treton Xavier Maria Nachury Mathurin Fumery Xavier Hébuterne Michael Rodrigues Hugot Jean-Pierre Gilles Boschetti Carmen Stefanescu Pauline Wils Philippe Seksik Lionel Le Bourhis Madeleine Bezault Pierre Sauvanet Bruno Pereira Matthieu Allez Nicolas Barnich Remind study group
Publication date : 01 November 2022 More
Authors : Collard Maxime Tourneur-Marsille Julien Mathieu Uzzan ALBUQUERQUE Miguel Roy Maryline Dumay Anne Jean-Noël Freund Hugot Jean-Pierre Guedj Nathalie Treton Xavier Panis Yves Ogier-Denis Eric
Publication date : 06 October 2020 More
Authors : Viennois Emilie Alexis Bretin Philip E. Dube Alexander C. Maue Charle` ne J.G. Dauriat Nicolas Barnich Andrew T. Gewirtz Benoit Chassaing
Publication date : 19 June 2020 More
Authors : Al Nabhani Z Berrebi D Martinez-Vinson C Montcuquet N Madre C Roy Maryline Ogier-Denis Eric Dussaillant M Cerf-Bensussan N Zouali H Daniel F Barreau F Hugot Jean-Pierre
Publication date : 10 April 2020 More
Authors : Collard Maxime Guedj Nathalie Tourneur-Marsille Julien ALBUQUERQUE Miguel Maggiori Leon Hammel Pascal Treton Xavier Panis Yves Ogier-Denis Eric
Publication date : 01 October 2019 More
Authors : Dumay Anne Gergaud Olivier Roy Maryline Hugot Jean-Pierre
Publication date : 17 July 2019 More
Authors : Romagnoni Alberto Jégou S Van Steen K Wainrib G Hugot Jean-Pierre International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Publication date : 30 April 2019 More
Authors : Maurel M Obacz J Avril T Ding YP Papadodima O Treton Xavier Daniel F Pilalis E Hörberg J Hou W Beauchamp MC Tourneur-Marsille Julien Cazals-Hatem Dominique Sommerova L Samali A Tavernier J Hrstka R Dupont A Fessart D Delom F Fernandez-Zapico ME Jansen G Eriksson LA Thomas DY Jerome-Majewska L Hupp T Chatziioannou A Chevet E Ogier-Denis Eric
Publication date : 08 May 2012 More
Authors : Jung C Meinzer Ulrich Montcuquet N Thachil E Château D Thiébaut R Roy Maryline Alnabhani Z Berrebi D Dussaillant M Pedruzzi E Thenet S Cerf-Bensussan N Hugot Jean-Pierre Barreau F
Publication date : 01 May 2012 More
Authors : Thachil E Hugot Jean-Pierre Arbeille B Paris R Grodet A Peuchmaur M Codogno P Barreau F Ogier-Denis Eric Berrebi D Viala Jérome
Publication date : 01 September 2011 More
Authors : Treton Xavier Pédruzzi E Cazals-Hatem Dominique Grodet A Panis Yves Groyer A Moreau Richard Bouhnik Yoram Daniel F Ogier-Denis Eric
Publication date : 13 December 2003 More
Authors : Hugot Jean-Pierre Alberti C Berrebi D Bingen E Cézard JP
Publication date : 31 May 2001 More
Authors : Hugot Jean-Pierre Chamaillard M Zouali H Lesage S Cézard JP Belaiche J Almer S Tysk C O'Morain CA Gassull M Binder V Finkel Y Cortot A Modigliani R Laurent-Puig P Gower-Rousseau C Macry J Colombel JF Sahbatou M Thomas G