Leader(s)
-
Gouya Laurent
- 01 57 27 73 32
- laurent.gouya@inserm.fr
-
Puy Hervé
- 01 49 09 58 98
- herve.puy@bch.aphp.fr
The iron that is present in all the cells of the body, is necessary for life. It is used primarily to provide oxygen transport, electron transfer reactions, or DNA synthesis. However, the excess iron represents a real threat for the cell since it is able to generate free radicals (or “reactive oxygen species” (ROS)) during the Fenton reaction (chemical reaction, which produces from iron and oxygenated water of the hydroxyl radical: H2O2 + Fe2+®OH– + OH· + Fe3+).
Iron is used mainly to produce heme, the prosthetic group of hemoproteins such as hemoglobin, myoglobin, cytochrome P450, …. In plasma, iron is bound to transferrin and its renewal is ensured on the one hand by intestinal absorption from the diet at the duodenal enterocytes (about 2 mg of iron absorbed per day) and by tissue macrophages recycling of hemoglobin, following phagocytosis of senescent red blood cells (approximately 25 mg / day). Both intestinal absorption of iron and recycling of heme-iron are controlled by hepcidin, a small peptide synthesized and secreted by the liver.
The expression of hepcidin is upregulated by iron overload and inflammation, but repressed by iron deficiency and by all the situations that stimulate erythropoiesis. The newly available hepcidin assay provides a new tool for optimizing intravenous iron treatment of anemia, particularly in inflammatory conditions.
Hepcidin is also expressed in many other organs, albeit at a much lower level. It could play a role of anti-bacterial defense.
The main pathologies linked to iron and heme metabolism disorders are: iron deficiency, hypochromic genetic microcytic anemia (sideroblastic or not), anemia of inflammation, iron overload (genetic and secondary hemochromatosis, inflammatory states), and porphyria.
Our projects allow to explore:
The HIROS team brings together doctors and researchers specialized in the metabolism of heme and iron and related pathologies. Our projects are dictated in large part by our connections to the French Porphyries Center (Louis Mourier Hospital), the molecular diagnostic activity of rare microcytic anemias APHP HUPNVS (Bichat Hospital), the « Epnet » network, the laboratory of excellence GRex, and DHU Unity.
L’équipe HIROS est responsable de la plateforme Biochimie & Métabolisme (http://www.cri1149.fr/v3/) et du dosage de l’hepcidine par spectroscopie de masse LCMSMS.
Publication date : 24 March 2021 More
Authors : Romain Duval Nicolas Gaël Willemetz Alexandra Yoshiko Murakami Mahmoud Mikdar Cedric Vrignaud Hisham Megahed Jean-Pierre Cartron Cecile Masson Samer Wehbi Berengere Koehl Marie Hully Karine Siquier Nicole Chemaly Agnes Rotig Stanislas Lyonnet Yves Colin Giulia Barcia Vincent Cantagrel Caroline Le Van Kim Olivier Hermine Taroh Kinoshita Thierry Peyrard Slim Azouzi
Publication date : 07 February 2019 More
Authors : Mirmiran Arienne Martin-Schmitt Caroline Lefebvre Thibaud Manceau Hana Daher Raed Oustric V Poli A Lacapère JJ Moulouel Boualem Puy Hervé Peoch'h Katell Lenglet H Simonin S Deybach Jean-Charles Nicolas Gaël Gouya Laurent
Publication date : 01 July 2018 More
Authors : Martin-Schmitt Caroline Lenglet H Yu A Delaby C Benecke A Lefebvre Thibaud Letteron Philippe Paradis Valérie Wahlin S Sandberg S Harper P Sardh E Sandvik AK Hov JR Aarsand AK Chiche L Bazille C Scoazec JY To-Figueras J Carrascal M Abian J Mirmiran Arienne Deybach Jean-Charles Puy Hervé Peoch'h Katell Manceau Hana Gouya Laurent
Publication date : 01 April 2018 More
Authors : Lefebvre Thibaud Reihani N Daher Raed de Villemeur TB Belmatoug N Rose C Colin-Aronovicz Y Puy Hervé Le Van Kim C Franco M
Publication date : 19 September 2017 More
Authors : Yien YY Ducamp S Van der Vorm LN Kardon JR Manceau Hana Kannengiesser Caroline Bergonia HA Kafina MD Gouya Laurent Baker TA Puy Hervé Phillips JD Nicolas Gaël Paw BH
Publication date : 02 March 2017 More
Authors : Ribeil JA Hacein-Bey-Abina S Payen E Magnani A Semeraro M Magrin E Caccavelli L Neven B Bourget P El Nemer W Bartolucci P Weber L Puy Hervé Meritet JF Grevent D Beuzard Y Chrétien S Lefebvre Thibaud Ross RW Negre O Veres G Sandler L Soni S De Montalembert M Blanche S Leboulch P Cavazzana M
Publication date : 01 March 2016 More
Authors : Houamel D Ducrot Nicolas Lefebvre Thibaud Daher Raed Moulouel Boualem Sari MA Letteron Philippe Lyoumi Said Millot Sarah Tourret J Bouvet O Vaulont S Vandewalle A Denamur E Puy Hervé Beaumont Carole Gouya Laurent
Publication date : 01 March 2016 More
Authors : Daher Raed Kannengiesser Caroline Houamel D Lefebvre Thibaud Bardou-Jacquet E Ducrot Nicolas De Kerguenec C Jouanolle AM Robreau AM Oudin C Le Gac C Moulouel Boualem Loustaud-Ratti V Bedossa Pierre Valla Dominique Gouya Laurent Beaumont Carole Brissot P Puy Hervé Tchernitchko Dimitri