Leader
-
El Benna Jamel
- 01 57 27 77 23
- jamel.elbenna@inserm.fr
Our team is interested in studying molecular and cellular mechanisms of inflammation, focusing on the regulationof the main reactive oxygen species (ROS) producing enzymes, the NADPH oxidases (NOXs) and their role in thephysiopathology of inflammatory diseases such as rheumatoid arthritis (RA) and inflammatory bowel diseases (IBD). When their production is controlled, reactive oxygen species (ROS) are involved in many important physiological functions. Thus ROS produced by the phagocyte NADPH oxidase, NOX2, in neutrophils, monocytes and macrophages are required for their bactericidal function, and importantly in dendritic cells, NOX2 has a critical role in antigen cross-presentation. Homologues of NOX2, such as NOX1, are also expressed in epithelial cells, but their physiological role is not fully understood. On the other hand, it is clear that excessive or inappropriate ROS production can induce severe tissue injury that participates to the physiopathology of inflammatory diseases. Deciphering mechanisms underlying activation of NOX2 in phagocytes and NOX1 in epithelial cells is essential to identify novel therapeutic targets in inflammation. The projects of the team aim to understand the regulation of NOX2 in neutrophils, monocytes/macrophages and dendritic cells and NOX1 in epithelial cells by pro- and anti-inflammatory agents; and to translate our basic research to animal models of inflammation, human phagocytic disorders and human inflammatory diseases. Our project combines basic and clinical research and involves several collaborations with teams in the Center for Research on Inflammation (CRI) and Bichat hospital divisions.
Our work is conducted following three main axis : 1)-To understand the regulation of the NADPH oxidases NOX in neutrophils, monocytes, macrophages, dendritic cells and epithelial cells in response to pro- and anti-inflammatory agents. 2)-To study polymorphism of NOX and regulators and identify new genetic factors involved in systemic inflammation. 3-To study the role of the NOX2, NOX1 and newly identified proteins in inflammatory process: by investigating their activation in phagocytic disorders, human inflammatory diseases and in animal models of inflammation.
Publication date : 01 June 2023 More
Autors : Camille Danne Chloé Michaudel Jurate Skerniskyte Julien Planchais Aurélie Magniez Allison Agus Marie-Laure Michel Bruno Lamas Gregory Da Costa Madeleine Spatz Cyriane Oeuvray Chloé Galbert Maxime Poirier Yazhou Wang Alexia Lapière Nathalie Rolhion Tatiana Ledent Cédric Pionneau Solenne Chardonnet Floriant Bellvert Edern Cahoreau Amandine Rocher Rafael Rose Arguello Carole Peyssonnaux Sabine Louis Mathias L Richard Philippe Langella El Benna Jamel Benoit Marteyn Harry Sokol
Publication date : 17 January 2023 More
Autors : Asma Tlili Pintard Coralie Hurtado-Nedelec Maria Margarita Liu Dan Viviana Marzaioli Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel
Publication date : 02 February 2022 More
Autors : Sahra Amel Belambri Viviana Marzailoli Hurtado-Nedelec Maria Margarita Pintard Coralie Shiyu Liang Yezhou Liu Tarek Boussetta Gougerot-Pocidalo Marie-Anne Richard D Ye Dang Pham My-Chan El Benna Jamel
Publication date : 29 January 2022 More
Autors : Rana M Nassif Elias Chalhoub Pia Chedid Hurtado-Nedelec Maria Margarita Elia Raya Dang Pham My-Chan Marie Jean-Claude El Benna Jamel
Publication date : 11 January 2022 More
Autors : Liu Dan Marie Jean-Claude Pelletier Anne-Laure Song Zhuoyao Ben-Khemis Marwah Kaouthar Boudiaf Pintard Coralie Thibaut Leger Samuel Terrier Guillaume Chevreux El Benna Jamel Dang Pham My-Chan
Publication date : 06 September 2021 More
Autors : Anna-Lena Neehus Kunihiko Moriya Alejandro Nieto-Patlán Tom Le Voyer Romain Lévy Ahmet Özen Elif Karakoc-Aydiner Safa Baris Alisan Yildiran Engin Altundag Manon Roynard Kathrin Haake Mélanie Migaud Karim Dorgham Guy Gorochov Laurent Abel Nico Lachmann Figen Dogu Sule Haskologlu Erdal İnce El Benna Jamel Gulbu Uzel Ayca Kiykim Kaan Boztug Marion R Roderick Mohammad Shahrooei Paul A Brogan Hassan Abolhassani Gonca Hancioglu Nima Parvaneh Alexandre Belot Aydan Ikinciogullari Jean-Laurent Casanova Anne Puel Jacinta Bustamante
Publication date : 11 August 2021 More
Autors : Tonia Akoumianaki Katerina Vaporidi Eleni Diamantaki Frédéric Pène Remi Beau Mark S Gresnigt Marina Gkountzinopulou Maria Venichaki Elias Drakos El Benna Jamel George Samonis Kieu T T Le Vinod Kumar Dimitrios Georgopoulos Frank L van de Veerdonk Mihai G Netea Jean-Paul Latge Georgios Chamilos
Publication date : 03 August 2020 More
Autors : Houssam Raad Hussein Mouawia Hamad Hassan Mohamed El-Seblani Riad Arabi-Derkawi Tarek Boussetta Gougerot-Pocidalo Marie-Anne Dang Pham My-Chan El Benna Jamel
Publication date : 01 July 2020 More
Autors : Pintard Coralie Ben-Khemis Marwah Liu Dan Dang Pham My-Chan Hurtado-Nedelec Maria Margarita El Benna Jamel
Publication date : 01 March 2020 More
Autors : Lydia Celia Madjene Luca Danelli Albert Dahdah Vibhushan Shamila Bex-Coudrat Julie Lebourdais-Pacreau Emeline Celine Vaugier Julien Claver Loïc Rolas Maguelonne Pons Iris Karina Madera-Salcedo Walid Beghdadi El Ghoneimi Alaa Benhamou Marc Launay Pierre Magnus Abrink Gunnar Pejler Ivan Cruz Moura Charles Nicolas Daugas Eric Perianin Axel Blank Ulrich
Publication date : 22 January 2020 More
Autors : Dang Pham My-Chan Rolas L El Benna Jamel
Publication date : 01 November 2019 More
Autors : Liu Min Bedouhene Samia Hurtado-Nedelec Maria Margarita Pintard Coralie Dang Pham My-Chan Yu S El Benna Jamel
Publication date : 06 September 2019 More
Autors : Ohayon D De Chiara A Dang Pham My-Chan Thieblemont N Chatfield S Marzaioli V Burgener SS Mocek J Candalh C Pintard Coralie Tacnet-Delorme P Renault G Lagoutte I Favier M Walker Francine Hurtado-Nedelec Maria Margarita Desplancq D Weiss Emmanuel Benarafa C Housset D Marie Jean-Claude Frachet P El Benna Jamel Witko-Sarsat V
Publication date : 01 March 2019 More
Autors : Arabi-Derkawi R O'Dowd Y Cheng N Rolas L Boussetta T Raad H Marzaioli V Pintard Coralie Fasseu M Kroviarski Y Belambri SA Dang Pham My-Chan Ye RD Gougerot-Pocidalo Marie-Anne El Benna Jamel
Publication date : 02 October 2018 More
Autors : Makhezer N Ben-Khemis Marwah Liu Dan Khichane Y Marzaioli V Tlili A Mojallali Marjan Pintard Coralie Letteron Philippe Hurtado-Nedelec Maria Margarita El Benna Jamel Marie Jean-Claude Sannier A Pelletier Anne-Laure Dang Pham My-Chan