Publications marquantes (équipe)

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Basophils contribute to pristane-induced Lupus-like nephritis model
Basophil involvement in lupus nephritis: a basis for innovation in daily care
IgE in the Pathogenesis of SLE: From Pathogenic Role to Therapeutic Target
Effects of BAFF Neutralization on Atherosclerosis Associated With Systemic Lupus Erythematosus
jeudi 9 mars 2023

The high affinity IgE receptor: a signaling update
jeudi 9 mars 2023

Basophils and IgE contribute to mixed connective tissue disease development
jeudi 9 mars 2023

SARS-CoV-2 infection among inpatients with systemic lupus erythematosus in France: a nationwide epidemiological study
jeudi 9 mars 2023

Autoimmunity, IgE and FcεRI-bearing cells
jeudi 9 mars 2023

AMG853, A Bispecific Prostaglandin D2 Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice
jeudi 9 mars 2023

CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development
jeudi 9 mars 2023

Systemic lupus erythematosus flare following SARS-CoV2 infection: the implication of IFNα and anti-IFNα autoantibodies
jeudi 9 mars 2023

Weaning of maintenance immunosuppressive therapy in lupus nephritis (WIN-Lupus): results of a multicentre randomised controlled trial
jeudi 9 mars 2023

Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation
jeudi 9 mars 2023

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
jeudi 9 mars 2023

Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets
jeudi 9 mars 2023

Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS project
jeudi 2 mars 2023

Analysis of the Efficacy and the Long-term Metabolic and Nutritional Status of Sleeve Gastrectomy with Transit Bipartition Compared to Roux-en-Y Gastric Bypass in Obese Rats
jeudi 2 mars 2023

Shortening the Biliopancreatic Limb Length of One Anastomosis Gastric Bypass Maintains Glucose Homeostasis Improvement with Limited Weight Loss
jeudi 26 janvier 2023

Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice
jeudi 26 janvier 2023

Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile
jeudi 26 janvier 2023

Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
jeudi 26 janvier 2023

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
jeudi 26 janvier 2023

Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs
jeudi 26 janvier 2023

Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies
jeudi 26 janvier 2023

Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions
jeudi 26 janvier 2023

Transarterial chemoembolisation enhances programmed death-1 and programmed death-ligand 1 expression in hepatocellular carcinoma
jeudi 26 janvier 2023

Long-term outcomes following resection of hepatocellular adenomas with small foci of malignant transformation or malignant adenomas
jeudi 26 janvier 2023

Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma
jeudi 26 janvier 2023

New insights into the pathophysiology and clinical care of rare primary liver cancers
jeudi 26 janvier 2023

A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis
jeudi 26 janvier 2023

Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma
jeudi 26 janvier 2023

Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset
jeudi 26 janvier 2023

Contribution of virtual biopsy to the screening of microvascular invasion in hepatocellular carcinoma: A pilot study
jeudi 26 janvier 2023

The role of endocytic trafficking in antigen T cell receptor activation
jeudi 26 janvier 2023

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches
jeudi 26 janvier 2023

Engineered niches support the development of human dendritic cells in humanized mice
jeudi 26 janvier 2023

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
jeudi 26 janvier 2023

The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
jeudi 19 janvier 2023

Impaired respiratory burst contributes to infections in PKCδ-deficient patients
jeudi 19 janvier 2023

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
jeudi 19 janvier 2023

Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2
jeudi 19 janvier 2023

CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
jeudi 19 janvier 2023

Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK
lundi 16 janvier 2023

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes
mercredi 11 janvier 2023

Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF
mercredi 11 janvier 2023

Targeting cell-intrinsic metabolism for antifibrotic therapy
lundi 28 novembre 2022

The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer
mercredi 10 août 2022

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides
mercredi 10 août 2022

A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma
mercredi 10 août 2022

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer
mercredi 16 mars 2022

Tumor Solid Stress: Assessment with MR Elastography under Compression of Patient-Derived Hepatocellular Carcinomas and Cholangiocarcinomas Xenografted in Mice
mercredi 16 mars 2022

Comparison of pulsed and oscillating gradient diffusion-weighted MRI for characterizing hepatocellular nodules in liver cirrhosis: ex vivo study in a rat model
mercredi 16 mars 2022

Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort
lundi 14 février 2022

Prevention and treatment of nutritional complications after bariatric surgery
lundi 14 février 2022

Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study.
jeudi 10 février 2022

Impaired p47phox phosphorylation in neutrophils from p67phox-deficient chronic granulomatous disease patients
lundi 24 janvier 2022

Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation
jeudi 13 janvier 2022

CD62L on blood basophils: a first pre-treatment predictor of remission in severe lupus nephritis
vendredi 16 juillet 2021

Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features
lundi 31 mai 2021

Inherited glycosylphosphatidylinositol defects cause the rare Emm-negative blood phenotype and developmental disorders
jeudi 6 mai 2021

Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma
lundi 15 février 2021

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
lundi 15 février 2021

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
vendredi 29 janvier 2021

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment
mardi 19 janvier 2021

Mast Cell Chymase and Kidney Disease
jeudi 10 décembre 2020

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells
jeudi 22 octobre 2020

Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation
jeudi 8 octobre 2020

COVID-19: découverte, diagnostic et développement de médicaments
vendredi 18 septembre 2020

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling.
vendredi 18 septembre 2020

The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils
jeudi 20 août 2020

Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development
jeudi 20 août 2020

Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial
jeudi 20 août 2020

Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure
jeudi 20 août 2020

Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases
jeudi 20 août 2020

Towards HBV curative therapies
jeudi 20 août 2020

Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?
jeudi 20 août 2020

Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis
mercredi 19 août 2020

Eliminating hepatitis C within low-income countries – The need to cure genotypes 4, 5, 6
mercredi 19 août 2020

MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C
mardi 28 juillet 2020

Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?
mardi 28 juillet 2020

Glutamate Signaling in Alcohol-associated Fatty Liver: “Pas de Deux”
vendredi 24 juillet 2020

Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine
mercredi 24 juin 2020

Immune-checkpoint inhibitor anti-PD1 aggravates colitis-associated colorectal cancer without enhancing intestinal inflammation
mardi 16 juin 2020

Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model
mardi 4 février 2020

Gastric bypass specifically impairs liver parameters as compared with sleeve gastrectomy, independently of evolution of metabolic disorders.
mardi 4 février 2020

Intestinal plasticity in response to nutrition and gastrointestinal surgery.
mardi 4 février 2020

Effect of different bariatric surgeries on dietary protein bioavailability in rats
lundi 3 février 2020

Combining imaging and tumour biopsy improves the diagnosis of combined hepatocellular-cholangiocarcinoma
lundi 3 février 2020

The dual role of ROS-generating NADPH oxidases in gastrointestinal inflammation and therapeutic perspectives.
lundi 3 février 2020

The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma
jeudi 7 novembre 2019

Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes.
jeudi 7 novembre 2019

Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction.
jeudi 7 novembre 2019

IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy.
jeudi 7 novembre 2019

Serum Iron Protects from Renal Postischemic Injury.
jeudi 7 novembre 2019

CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis.
jeudi 7 novembre 2019

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice.
jeudi 7 novembre 2019

Extracellular fluid volume is associated with incident end-stage kidney disease and mortality in patients with chronic kidney disease.
lundi 4 novembre 2019

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.
lundi 4 novembre 2019

Erythroid-Progenitor-Targeted Gene Therapy Using Bifunctional TFR1 Ligand-Peptides in Human Erythropoietic Protoporphyria.
lundi 4 novembre 2019

A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis.
lundi 4 novembre 2019

Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease.
mardi 22 octobre 2019

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.
mardi 22 octobre 2019

Is Crohn’s Disease the Price to Pay Today for Having Survived the Black Death?
mardi 22 octobre 2019

Macrophage autophagy protects against liver fibrosis in mice.
mardi 22 octobre 2019

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.
mardi 22 octobre 2019

Age and liver transplantation
mardi 22 octobre 2019

Autophagy in liver diseases: Time for translation?
mardi 22 octobre 2019

The prolyl isomerase Pin1 controls lipopolysaccharide-induced priming of NADPH oxidase in human neutrophils.
mardi 22 octobre 2019

Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome.
mardi 22 octobre 2019

Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver.
mardi 22 octobre 2019

Origin and development of classical dendritic cells.
lundi 21 octobre 2019

Is there a place and role for endocytic TCR signaling?
lundi 21 octobre 2019

The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.
lundi 21 octobre 2019

Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.
lundi 21 octobre 2019

Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms.
vendredi 11 octobre 2019

Quantitative MRI in murine radiation-induced rectocolitis: comparison with histopathological inflammation score.
jeudi 10 octobre 2019

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.
vendredi 4 octobre 2019

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
jeudi 3 octobre 2019

Mucosal-associated invariant T cells and disease
mardi 14 mai 2019

Assessing Tumor Mechanics by MR Elastography at Different Strain Levels
lundi 1 avril 2019

In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium-liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T
jeudi 14 mars 2019

Lyn and Fyn function as molecular switches that control antigen receptors directing homeostasis or inflammation
jeudi 14 mars 2019

Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis
jeudi 14 mars 2019

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver
jeudi 14 mars 2019

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
mercredi 13 mars 2019

Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy
mercredi 13 mars 2019

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome.
mercredi 13 mars 2019

Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome.
mercredi 13 mars 2019

Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen
mercredi 13 mars 2019

Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver.
mercredi 13 mars 2019

Gene Therapy in a Patient with Sickle Cell Disease.
mercredi 13 mars 2019

Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.
mercredi 13 mars 2019

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.
mercredi 13 mars 2019

Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans.
mercredi 13 mars 2019

Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
mercredi 13 mars 2019

Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn’s Disease Short title: Crinophagy in Crohn’s disease
mercredi 13 mars 2019

Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis
mercredi 13 mars 2019

Crohn Disease : the cold chain hypothesis
mercredi 13 mars 2019

Association of Nod-2 leucine-rich repeat variants with susceptibility to Crohn’s disease
mercredi 13 mars 2019

NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions
mercredi 13 mars 2019

Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo
mercredi 13 mars 2019

Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury
mercredi 13 mars 2019

Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
mercredi 13 mars 2019

Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation
mercredi 13 mars 2019

Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C
mercredi 13 mars 2019

Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis.
mercredi 13 mars 2019

The emerging roles of microvesicles in liver diseases.
mercredi 13 mars 2019

Liver sinusoidal endothelial cells: physiology and role in liver diseases
mercredi 13 mars 2019

Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury.
mardi 20 novembre 2018

Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment

Les dernières publications marquantes

Date de publication : 17 janvier 2023 En savoir +

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes

PNAS

Auteurs : Asma Tlili Pintard Coralie Hurtado-Nedelec Maria Margarita Liu Dan Viviana Marzaioli Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel
Date de publication : 30 novembre 2022 En savoir +

Comparative Analysis of a Locally Resampling MR Elastography Reconstruction Algorithm in Liver Fibrosis

JMRI

Auteurs : Page Gwenael Julea Felicia Paradis Valérie Vilgrain Valérie Valla Dominique Van Beers Bernard Garteiser Philippe
Date de publication : 03 novembre 2022 En savoir +

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Nature Communications.

Auteurs : Rida Al-Rifai Marie Vandestienne Jean-Rémi Lavillegrand Tristan Mirault Julie Cornebise Poisson Johanne Ludivine Laurans Bruno Esposito Chloé James Olivier Mansier Pierre Hirsch Fabrizia Favale Rayan Braik Camille Knosp Jose Vilar Giuseppe Rizzo Alma Zernecke Antoine-Emmanuel Saliba Alain Tedgui Maxime Lacroix Lionel Arrive Ziad Mallat Soraya Taleb Marc Diedisheim Clément Cochain Rautou Pierre-Emmanuel Hafid Ait-Oufella

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