Team leader

Presentation

“from left to right: Marion Tanguy, Johanne Poisson, Pierre-Emmanel Rautou, Tazime Issoufaly, Sara Thietart, Louise Biquard”

 

Our team is working on the role of vessels in liver disease. We are interested in rare vascular liver diseases (Budd-Chiari syndrome, extrahepatic vein thrombosis and porto-sinusoidal vascular diseases), nonalcoholic steatohepatitis and cirrhosis.

Current research directions :

  • Liver sinusoidal endothelial cells in the progression of liver diseases
  • Extracellular vesicles in liver diseases
  • Porto-sinusoidal vascular disease

 

 

    1. Liver sinusoidal endothelial cells in the progression of liver diseases

      Recent advances indicate that intestinal and visceral adipose tissues play a key role in liver diseases. This suggests that substances are released by these tissues, influencing liver function. Liver endothelial cells are among the first cells to encounter blood from intestinal and visceral fat tissues. They are an active interface between blood and other hepatic cells. However, the role of liver endothelial cells in liver diseases is paradoxically very poorly understood. Our team has therefore set itself the objective of highlighting the involvement of liver endothelial cells in non-alcoholic steatohepatitis and cirrhosis.

    1. Extracellular vesicles in liver diseases

      Extracellular vesicles are membrane-bound vesicles released by cells into the extracellular space. They include apoptotic bodies, microvesicles, also previously known as microparticles, and exosomes. Extracellular vesicles are able to transmit information from one cell to another. We are currently determining the role of extracellular vesicles in progression and complications of liver diseases. To do so, we analyze their roles in intercellular communication between the liver and other organs, as well as among the liver itself. Extracellular vesicles can also be used as biomarkers. We have already demonstrated that hepatocyte microvesicles can predict the course of patients with cirrhosis. We are now validating these results in large cohorts of patients. To finish, we are developing new detection strategies of extracellular vesicles of other origins to predict more accuratly the evolution of liver diseases.

  1. Porto-sinusoidal vascular disease
    Previously called non-cirrhotic portal hypertension or nodular regenerative hyperplasia, is a rare disease characterized by alterations in the portal veins and/or sinusoids leading in some patients to portal hypertension and its complications. We are studying the pathophysiology of this disease as well as the future of patients with this disease.