Basophils, Mast cells and Immunopathology (BMI)
Team Charles / Blank
Department Nephrology, Immunology and Hematology
Besides their well-known role in allergies, mast cells (MC) and basophils (Ba) are important orchestrators of the inflammatory process with possible beneficial and pathological consequences. The team’s project focuses on the role of mast cells and basophils in immunopathology mainly in a non-allergic context using both fundamental and clinical approaches with local clinical departments. The strategy is based on the identification of the receptors expressed on these cells, their signaling pathways and the mechanism controlling the subsequent release of inflammatory mediators and on the effect of these mediators on tissue function, particularly on kidney, in animal models and patient samples. Both approaches are tightly linked to the analysis of therapeutic/prognostic/diagnostic potential of each of these steps using in vitro and in vivo approaches. Our team is particularly focused on the study of the role of basophils in lupus nephritis and of mast cells in renal diseases and fibrosis development as well as in tissue transplantation.
The major research axes developed in our team are the following:
(A) Study of the molecular mechanisms and effectors regulating inflammatory mediator secretion in mast cells and basophils. This includes the study of new receptors of basophil function as well as the study of early and late signaling events involved in degranulation and cytokine chemokine secretion (axes 1-3).
(B) Study of the role of mast cells and basophils in immunopathology. This includes the analysis of the role of mast cells and their interaction with other inflammatory cells in fibrosis development, acute kidney injury and transplantation. The crosstalk of basophils with other innate and adaptive immune cells in the development of autoimmune diseases (in particular systemic lupus erythematous) is studied. We also investigate the role of these two cell compartments in the amplification of lupus disease flares and severe cardiovascular outcomes in a translational approach (axes 4-6).
Publication date : 20 November 2018 More
Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment Front Immunol. 9:2690
Autors : Ngo Nyekel Flavie Lebourdais-Pacreau Emeline Benadda Samira Msallam Rasha Åbrink Magnus Pejler Gunnar Davoust Jean Benhamou Marc Charles Nicolas Launay Pierre Blank Ulrich Gautier Gregory
Publication date : 03 July 2018 More
Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation Sci Signal. 2018, 11(537)
Autors : Madera-Salcedo IK Danelli L Tiwari N Dema N Lebourdais-Pacreau Emeline Vibhushan Shamila Birnbaum J Agabriel C Liabeuf V Klingebiel C Menasche G Macias-Silva M Benhamou Marc Charles Nicolas González-Espinosa C Vitte J Blank Ulrich
Publication date : 20 February 2018 More
Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs Nat Commun. 2018, 9(1):725
Autors : Pellefigues Christophe Dema B Lamri Yasmine Saidoune Fanny Chavarot Nathalie Lohéac C Lebourdais-Pacreau Emeline Dussiot M Bidault C Marquet F Jablonski M Chemouny JM Jouan F Dossier A Chauveheid MP Gobert D Papo Thomas Karasuyama H Sacre Karim Daugas Eric Charles Nicolas
Publication date : 15 March 2017 More
Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury J Immunol. 2017, 198(6):2374-2382
Autors : Danelli L Madjene LC Madera-Salcedo I Gautier Gregory Lebourdais-Pacreau Emeline Ben Mkaddem Sanae Charles Nicolas Daugas Eric Launay Pierre Blank Ulrich
Publication date : 10 March 2017 More
Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo PLoS One. 2017, 12(3):e0173815
Autors : Kassas-Guediri A Bex-Coudrat Julie Lebourdais-Pacreau Emeline Launay Pierre Monteiro Renato Blank Ulrich Charles Nicolas Benhamou Marc